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The nature of the ground states of cobalt(II) and nickel(II) carboxypeptidase A

Rosenberg, Robert C. and Root, Charles A. and Wang, Run-Han and Cerdonio, Massimo and Gray, Harry B. (1973) The nature of the ground states of cobalt(II) and nickel(II) carboxypeptidase A. Proceedings of the National Academy of Sciences of the United States of America, 70 (1). pp. 161-163. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:ROSpnas73

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Abstract

The magnetic susceptibilities of cobalt(II) and nickel(II) derivatives of carboxypeptidase A (CPA) follow the Curie law over a wide temperature range. The observed magnetic moments of Co(II)CPA and Ni(II)CPA are 4.77 ± 0.15 and 2.53 ± 0.10 Bohr Magnetons, respectively. The magnetic and spectral properties of Ni(II)CPA are consistent only with an octahedral ground-state geometry, whereas Co(II)CPA has a probable five-coordinate structure. The results establish ordinary metal-ion ground states for two metallocarboxypeptidase A derivatives which exhibit full peptidase activity.


Item Type:Article
Additional Information:Copyright © 1973 by the National Academy of Sciences. Contributed by Harry B. Gray, November 10, 1972. We thank Barry Dohner for technical assistance. Special thanks are due to Dr. R. J. P. Williams for a stimulating discussion. Our research was supported by the National Science Foundation and Office of Naval Research contract no. N00014-67-A-0094-0013. C.A.R. acknowledges a sabbatical leave from Bucknell University and partial support from a National Science Foundation Science Faculty Fellowship. This is Contribution no. 4588 from the Arthur Amos Noyes Laboratory.
Subject Keywords:metallocarboxypeptidase A, magnetic susceptibility, coordination geometry, spectra
Record Number:CaltechAUTHORS:ROSpnas73
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:ROSpnas73
Alternative URL:http://www.pnas.org/cgi/content/abstract/70/1/161
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1023
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:01 Dec 2005
Last Modified:26 Dec 2012 08:42

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