Rosenberg, Robert C. and Root, Charles A. and Wang, Run-Han and Cerdonio, Massimo and Gray, Harry B. (1973) The nature of the ground states of cobalt(II) and nickel(II) carboxypeptidase A. Proceedings of the National Academy of Sciences of the United States of America, 70 (1). pp. 161-163. ISSN 0027-8424 http://resolver.caltech.edu/CaltechAUTHORS:ROSpnas73
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The magnetic susceptibilities of cobalt(II) and nickel(II) derivatives of carboxypeptidase A (CPA) follow the Curie law over a wide temperature range. The observed magnetic moments of Co(II)CPA and Ni(II)CPA are 4.77 ± 0.15 and 2.53 ± 0.10 Bohr Magnetons, respectively. The magnetic and spectral properties of Ni(II)CPA are consistent only with an octahedral ground-state geometry, whereas Co(II)CPA has a probable five-coordinate structure. The results establish ordinary metal-ion ground states for two metallocarboxypeptidase A derivatives which exhibit full peptidase activity.
|Additional Information:||Copyright © 1973 by the National Academy of Sciences. Contributed by Harry B. Gray, November 10, 1972. We thank Barry Dohner for technical assistance. Special thanks are due to Dr. R. J. P. Williams for a stimulating discussion. Our research was supported by the National Science Foundation and Office of Naval Research contract no. N00014-67-A-0094-0013. C.A.R. acknowledges a sabbatical leave from Bucknell University and partial support from a National Science Foundation Science Faculty Fellowship. This is Contribution no. 4588 from the Arthur Amos Noyes Laboratory.|
|Subject Keywords:||metallocarboxypeptidase A, magnetic susceptibility, coordination geometry, spectra|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||01 Dec 2005|
|Last Modified:||26 Dec 2012 08:42|
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