Dahlquist, F. W. and Rand-Meir, T. and Raftery, M. A. (1968) Demonstration of carbonium ion intermediate during lysozyme catalysis. Proceedings of the National Academy of Sciences of the United States of America, 61 (4). pp. 1194-1198. ISSN 0027-8424 http://resolver.caltech.edu/CaltechAUTHORS:DAHpnas68
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Abstract
X-ray analysis studies (1,2) on the relative modes of association of various inhibitors and substrates with lysozyme have led to a proposal for the catalytic mechanism of the enzyme (3,4). This proposal suggests that the enzyme catalyzes the formation of a carbonium ion at C1 of the glycosidic bond undergoing hydrolysis and, further, provides it with steric and electrostatic stabilization. To date, little evidence of a chemical nature has been available to test the mechanistic proposal.
| Item Type: | Article |
|---|---|
| Additional Information: | © 1968 by the National Academy of Sciences. Communicated by George S. Hammond, October 7, 1968. Supported by U.S. Public Health Service grant GM-14452. [F.W.D. was a] National Institutes of Health trainess, 1967-68. Church Laboratories of Chemical Biology, Contribution No. 3760. |
| Record Number: | CaltechAUTHORS:DAHpnas68 |
| Persistent URL: | http://resolver.caltech.edu/CaltechAUTHORS:DAHpnas68 |
| Alternative URL: | http://www.pnas.org/cgi/reprint/61/4/1194 |
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. |
| ID Code: | 10262 |
| Collection: | CaltechAUTHORS |
| Deposited By: | Tony Diaz |
| Deposited On: | 21 Apr 2008 |
| Last Modified: | 26 Dec 2012 09:58 |
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