Dahlquist, F. W. and Rand-Meir, T. and Raftery, M. A. (1968) Demonstration of carbonium ion intermediate during lysozyme catalysis. Proceedings of the National Academy of Sciences of the United States of America, 61 (4). pp. 1194-1198. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:DAHpnas68
See Usage Policy.
Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:DAHpnas68
X-ray analysis studies (1,2) on the relative modes of association of various inhibitors and substrates with lysozyme have led to a proposal for the catalytic mechanism of the enzyme (3,4). This proposal suggests that the enzyme catalyzes the formation of a carbonium ion at C1 of the glycosidic bond undergoing hydrolysis and, further, provides it with steric and electrostatic stabilization. To date, little evidence of a chemical nature has been available to test the mechanistic proposal.
|Additional Information:||© 1968 by the National Academy of Sciences. Communicated by George S. Hammond, October 7, 1968. Supported by U.S. Public Health Service grant GM-14452. [F.W.D. was a] National Institutes of Health trainess, 1967-68. Church Laboratories of Chemical Biology, Contribution No. 3760.|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||21 Apr 2008|
|Last Modified:||14 Nov 2014 19:20|
Repository Staff Only: item control page