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Demonstration of carbonium ion intermediate during lysozyme catalysis

Dahlquist, F. W. and Rand-Meir, T. and Raftery, M. A. (1968) Demonstration of carbonium ion intermediate during lysozyme catalysis. Proceedings of the National Academy of Sciences of the United States of America, 61 (4). pp. 1194-1198. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:DAHpnas68

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Abstract

X-ray analysis studies (1,2) on the relative modes of association of various inhibitors and substrates with lysozyme have led to a proposal for the catalytic mechanism of the enzyme (3,4). This proposal suggests that the enzyme catalyzes the formation of a carbonium ion at C1 of the glycosidic bond undergoing hydrolysis and, further, provides it with steric and electrostatic stabilization. To date, little evidence of a chemical nature has been available to test the mechanistic proposal.


Item Type:Article
Additional Information:© 1968 by the National Academy of Sciences. Communicated by George S. Hammond, October 7, 1968. Supported by U.S. Public Health Service grant GM-14452. [F.W.D. was a] National Institutes of Health trainess, 1967-68. Church Laboratories of Chemical Biology, Contribution No. 3760.
Record Number:CaltechAUTHORS:DAHpnas68
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:DAHpnas68
Alternative URL:http://www.pnas.org/cgi/reprint/61/4/1194
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10262
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Apr 2008
Last Modified:26 Dec 2012 09:58

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