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Genetic Control of Biochemical Reactions in Neurospora: An "Aminobenzoicless" Mutant

Tatum, E. L. and Beadle, G. W. (1942) Genetic Control of Biochemical Reactions in Neurospora: An "Aminobenzoicless" Mutant. Proceedings of the National Academy of Sciences of the United States of America, 28 (6). pp. 234-243. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:TATpnas42

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Abstract

An x-ray induced mutant strain of Neurospora crassa has been obtained which requires p-aminobenzoic acid for growth. Its growth is a function of the amount of p-aminobenzoic acid supplied, and it is indistinguishable from normal when adequate amounts of p-aminobenzoic acid are available. The mutant differs from normal by a single gene, which must therefore control an essential step in the synthesis of p-aminobenzoic acid, and which is presumably primarily concerned only with the synthesis of p-aminobenzoic acid. Sulfanilamide inhibits the growth of both the normal and mutant strains, and in both cases the inhibition is overcome by an excess of p-aminobenzoic acid. A number of substances related to p-aminobenzoic acid are able to replace it, but their activities are much less than that of p-aminobenzoic acid itself. The addition of benzoic or p-OH-benzoic acids or tyrosine did not increase the amount of p-aminobenzoic acid produced by the normal strain. It is concluded that none of the compounds tested is concerned with the normal synthesis of p-aminobenzoic acid, and that this biosynthesis probably does not involve the introduction of an amino group into a preformed benzene ring.


Item Type:Article
Additional Information:Copyright © 1942 by the National Academy of Sciences. Work supported by grants from the Rockefeller Foundation and from the Penrose Fund of the American Philosophical Society. The authors are indebted to Dr. Russell Perry Hager and Miss Caryl L. Parker for assistance.
Record Number:CaltechAUTHORS:TATpnas42
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:TATpnas42
Alternative URL:http://www.pnas.org/content/vol28/issue6/
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10389
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:01 May 2008
Last Modified:26 Dec 2012 10:00

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