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The N-end rule: Functions, mysteries, uses

Varshavsky, Alexander (1996) The N-end rule: Functions, mysteries, uses. Proceedings of the National Academy of Sciences of the United States of America, 93 (22). pp. 12142-12149. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:VARpnas96

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Abstract

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. I discuss the mechanisms and functions of this pathway, and consider its applications.


Item Type:Article
Additional Information:Copyright © 1996 by the National Academy of Sciences Contributed by Alexander Varshavsky, August 6, 1996. This contribution is part of the special series of Inaugural Articles by members of the National Academy of Sciences elected on April 25, 1995. I am grateful to the current and former members of the laboratory whose work on the N-end rule is described in this review. I thank colleagues whose names are cited in the text for their permission to discuss unpublished data. Our studies are supported by grants from the National Institutes of Health and the Association for the Cure of Cancer of the Prostate.
Subject Keywords:ubiquitin, proteolysis, N-degron, peptide import, apoptosis
Record Number:CaltechAUTHORS:VARpnas96
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:VARpnas96
Alternative URL:http://www.pnas.org/cgi/content/abstract/93/22/12142
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1039
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:09 Dec 2005
Last Modified:14 Nov 2014 19:18

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