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The twisted circular form of polyoma viral DNA

Vinograd, J. and Lebowitz, J. and Radloff, R. and Watson, R. and Laipis, P. (1965) The twisted circular form of polyoma viral DNA. Proceedings of the National Academy of Sciences of the United States of America, 53 (5). pp. 1104-1111. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:VINpnas65

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Abstract

The major part of the DNA from polyoma virus has been shown to consist of circular base-paired duplex molecules without chain ends.(1-3) The intertwined circular form accounts for the ease of renaturation(4) of this DNA and the failure of the strands to separate in strand-separating solvents.(1-3)


Item Type:Article
Additional Information:© 1965 by the National Academy of Sciences. Communicated by Norman Davidson, March 30, 1965. This work was reported in part at the 9th Annual Meeting of the Biophysical Society, February 24, 1965. Contribution 3227 of Gates and Crellin Laboratories of Chemistry. It is a pleasure to thank I. R. Lehman for the generous gift of the E. coli enzymes, R.L. Sinsheimer, J. Petruska, and M. Fried for helpful discussions, R. Dulbecco for allowing us to quote his unpublished results, and T. Benjamin, L. Wenzel, and A. Drew for advice and assistance in the culture of the virus and the assay of the DNA. This work was supported in part by grants HE 03394 and CA 08014 from the U.S. Public Health Service.
Record Number:CaltechAUTHORS:VINpnas65
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:VINpnas65
Alternative URL:http://www.pnas.org/cgi/reprint/53/5/1104
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10510
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 May 2008
Last Modified:26 Dec 2012 10:01

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