CaltechAUTHORS
  A Caltech Library Service

Could CuB be the site of redox linkage in cytochrome c oxidase?

Larsen, Randy W. and Pan, Lian-Ping and Musser, Siegfried M. and Li, Zhuyin and Chan, Sunney I. (1992) Could CuB be the site of redox linkage in cytochrome c oxidase? Proceedings of the National Academy of Sciences of the United States of America, 89 (2). pp. 723-727. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:LARpnas92

[img]
Preview
PDF
See Usage Policy.

947Kb

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:LARpnas92

Abstract

This paper explores the proton pumping function of cytochrome c oxidase [ferrocytochrome-c:oxygen oxidoreductase (EC 1.9.3.1)] based upon redox linkage at the "high-potential" CU(B) center. A model is proposed that is derived from a redox-linked ligand exchange mechanism previously described for the Cu(A) site. Qualitative analysis of this mechanism indicates that such a mechanism is feasible. However, the relatively short distance between Cu(B) and cytochrome a3 implies that the uncoupling electron transfers are quite facile. In addition, the position of the Cu(B) center with respect to the inner mitochondrial membrane argues against redox linkage at the Cu(B) site.


Item Type:Article
Additional Information:Copyright © 1992 by the National Academy of Sciences. Communicated by Fred Anson, August 5, 1991 (received for review May 30, 1991). This is contribution no. 8443 from the Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology. This work was supported by Grant GM 22432 from the National Institute of General Medical Sciences, U.S. Public Health Service, and Grant PRF#19671-AC3 from the Petroleum Research Fund of the American Chemical Society. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Subject Keywords:proton pump, electron transfer, mitochondria, respiration, oxygen reduction, dioxygen reduction, mechanism, model, temperature, oxygen
Record Number:CaltechAUTHORS:LARpnas92
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:LARpnas92
Alternative URL:http://www.pnas.org/cgi/content/abstract/89/2/723
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1068
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:15 Dec 2005
Last Modified:26 Dec 2012 08:42

Repository Staff Only: item control page