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Class of {varphi}X174 Mutants Relatively Deficient in Synthesis of Viral RNA

Clements, J. Barklie and Sinsheimer, Robert L. (1974) Class of {varphi}X174 Mutants Relatively Deficient in Synthesis of Viral RNA. Journal of Virology, 14 (6). pp. 1630-1632. ISSN 0022-538X. http://resolver.caltech.edu/CaltechAUTHORS:CLEjvir74

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Abstract

Nonpermissive cells infected with {varphi}X174 gene D amber mutants synthesized some sixfold less viral RNA than permissive cells. The decrease was unaffected by increasing the multiplicity of infection and was a consequence of an overall decrease in all viral RNA species. It is suggested that the gene D product may function in replicative form DNA unwinding to expose the template for transcription.


Item Type:Article
Additional Information:Copyright © 1975 American Society for Microbiology. Received for publication 17 June 1974. This research was supported in part by Public Health Service grant GM13554 from the National Institute of General Medical Sciences.
Record Number:CaltechAUTHORS:CLEjvir74
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:CLEjvir74
Alternative URL:http://jvi.asm.org/cgi/content/abstract/14/6/1630
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10725
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:05 Jun 2008
Last Modified:26 Dec 2012 10:04

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