Wells, Ibert C. and Itano, Harvey A. (1951) Ratio of sickle-cell anemia hemoglobin to normal hemoglobin in sicklemics. Journal of Biological Chemistry, 188 (1). pp. 65-74. ISSN 0021-9258 http://resolver.caltech.edu/CaltechAUTHORS:WELjbc51
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It has been observed that all of the erythrocytes of individuals with sickle-cell trait undergo sickling and that a greater reduction in partial pressure of oxygen is required to produce complete sickling in sickle-cell trait erythrocytes than in those of sickle-cell anemics (1). These observations indicate that each sicklemia erythrocyte contains both normal hemoglobin and sickle-cell anemia hemoglobin. In a pooled sample of blood from five sicklemic individuals the ratio of t,he abnormal to the normal hemoglobin was found to be 39:61 (7). In the light of this knowledge it was considered pertinent to ascertain the extent of the variation of the ratio of sickle-cell anemia hemoglobin (SCA hemoglobin) to normal hemoglobin in sicklemic individuals and the effect of various factors on this ratio. Such information not only would increase the knowledge of sickle-cell disease but also might shed some light on the general problem of the control of hemoglobin anabolism.
|Additional Information:||Copyright © 1951 by the American Society for Biochemistry and Molecular Biology. (Received for publication, August 21, 1950) The authors take pleasure in acknowledging their indebtedness to Dr. Linus Pauling for his many suggestions and careful reading of the manuscript, to Dr. J.V. Neel of the University of Michigan, Ann Arbor, Michigan, and to Dr. Ray D. Owen, of the Biology Division of this Institute, for their helpful suggestions. Presented in part at the meeting of the National Academy of Sciences in Washington, D. C., April, 1950, and at the meeting of the American Society of Biological Chemists in Atlantic City, April, 1950. [I.C.W. was a] Postdoctoral Fellow of the Division of Medical Sciences of the National Research Council. [H.A.T. was] Assigned to the California Institute of Technology by the National Cancer Institute, United States Public Health Service. Gates and Crellin Laboratories of Chemistry, Contribution No. 1456. Aided in part by a grant from the United States Public Health Service.|
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