Rittenberg, Marvin B. and Campbell, Dan H. (1968) Heterologous carriers in the anamnestic antihapten response. Journal of Experimental Medicine, 127 (4). pp. 717-730. ISSN 0022-1007. http://resolver.caltech.edu/CaltechAUTHORS:RITjem68
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Anamnestic antihapten responses were obtained to trinitrophenyl (TNP) when rabbits sensitized to trinitrophenyl-hemocyanin (TNP-KLH) were challenged with TNP-heterologous protein conjugates. Hapten-heterologous carrier conjugates elicited antihapten titers similar in magnitude to those elicited by the homologous carrier conjugate. Hapten-heterologous carrier recall of antihapten was successful as early as 37 days and as late as 11 months after sensitization. There was no correlation between anti-TNP-precipitating antibody titer after sensitization and the ability to respond to challenge by hapten-heterologous carrier. The results are discussed in terms of immunogenicity of sensitization, suppressive effects of persisting postsensitization antibody, and submolecular haptenic environment as factors possibly affecting the heterologous recall process.
|Additional Information:||Copyright © 1968 by The Rockefeller University Press. RUP grants the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode. Submitted on December 10, 1967. The authors gratefully acknowledge the excellent assistance of Mr. Bror Clark, Mr. Urs Rutishanser, Miss Jan Williams, and Miss Katherine Pratt. We wish to thank Dr. A. Malley and Dr. A.A. Amkraut for critically reading this manuscript, and Dr. G. Strejan for helpful discussions during the course of the investigation. This investigation was supported in part by Grant AI 1355-19 from the National Institute of Allergy and Infectious Diseases and by a Hartford Foundation Grant. [M.R.B. was a] Leukemia Society Scholar. A portion of this work was carried out by Dr. Rittenberg during tenure of a National Institutes of Health Postdoctoral Fellowship at the California Institute of Technology. Gates and Crellin Laboratories of Chemistry, Contribution 3614.|
|Usage Policy:||RUP grants the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode.|
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