Chapman, Barbara S. and Tobin, Allan J. and Hood, Leroy E. (1981) Complete amino acid sequence of the major early embryonic beta-like globin in chickens. Journal of Biological Chemistry, 256 (11). pp. 5524-5531. ISSN 0021-9258. http://resolver.caltech.edu/CaltechAUTHORS:CHAjbc81
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The rho globin is the major beta-like chain found in 5-day-old chick embryos. In association with two unique early embryonic alpha-like globins, it forms the two major hemoglobins of early chick development. This paper presents the complete amino acid sequence of the rho globin. There are no amino acid differences between the rho chain and the adult chicken beta chain at known Bohr effect or organophosphate-binding positions, and there are only 19 differences altogether. The rho globin ought to be functionally equivalent to the adult chicken beta globin. Since the adult and embryonic chains are very similar in sequence, they may be products of a relatively recent gene duplication in the chicken beta globin gene family. The possibility of a gene correction event is discussed.
|Additional Information:||Copyright © 1981 by the American Society for Biochemistry and Molecular Biology. (Received for publication, July 7, 1980, and in revised form, October 13, 1980) We owe sincere thanks to Dr. James Schilling for teaching BSC amino acid sequencing techniques. Thanks also to Margaret Kowalczyk for precision illustrations and to Lori Erdley for patient assistance in the preparation of the manuscript. This research was supported by National Research Service Award F32 HL05553 (to B.S.C.), Grants PCM 76-02859 and 78-20767 from the National Science Foundation (to A.J.T.), and Grant GM-06965 from the National Institutes of Health (to L.E.H.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.|
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|Deposited On:||15 Jun 2008|
|Last Modified:||26 Dec 2012 10:06|
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