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Growth of Pseudotypes of Vesicular Stomatitis Virus with N-Tropic Murine Leukemia Virus Coats in Cells Resistant to N-Tropic Viruses

Huang, Alice S. and Besmer, Peter and Chu, Louise and Baltimore, David (1973) Growth of Pseudotypes of Vesicular Stomatitis Virus with N-Tropic Murine Leukemia Virus Coats in Cells Resistant to N-Tropic Viruses. Journal of Virology, 12 (3). pp. 659-662. ISSN 0022-538X. http://resolver.caltech.edu/CaltechAUTHORS:HUAjvir73

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Abstract

Formation of pseudotypes between murine RNA tumor viruses and vesicular stomatitis virus (VSV) has been confirmed. Pseudotypes of VSV genomes coated by the surface envelope from an N-tropic tumor virus grew equally well in cells homozygous for either the Fv-1n or Fv-1b alleles. Therefore, the product of the Fv-1 locus, which restricts growth of murine RNA tumor viruses, must act on an intracellular aspect of tumor virus replication, a step after attachment and penetration.


Item Type:Article
Additional Information:Copyright © 1973 by the American Society for Microbiology. Received for publication 19 June 1973. We thank Mort Litt and S.M. Perlman for help with antiserum and viral preparations and Tazwell Wilson for excellent technical assistance. We are especially grateful to Janet Hartley for supplying N-tropic MuLV. This work was supported by a National Science Foundation research grant GB 34266, American Cancer Society research grants VC-63 and VC-4D, and a contract from the Viral Cancer Program. A.S.H. is a Research Career Development Awardee of the Public Health Service (AI 70413). P.B. was supported by the Schweizerische Krebsliga. D.B. is an American Cancer Society Professor of Microbiology. This work grew out of a summer sojourn at the Salk Institute for Biological Studies.
Record Number:CaltechAUTHORS:HUAjvir73
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:HUAjvir73
Alternative URL:http://jvi.asm.org/cgi/content/abstract/12/3/659
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10912
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:16 Jun 2008
Last Modified:26 Dec 2012 10:06

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