Niemann, Carl and Nichols, Peter L., Jr. (1942) The synthesis of D-erythro- and D-threo-α-amino-β,γ-dihydroxy-n-butyric acids. Journal of Biological Chemistry, 143 (1). pp. 191-202. ISSN 0021-9258. http://resolver.caltech.edu/CaltechAUTHORS:NIEjbc42
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We repeated the synthesis of Fischer and Feldmann  and obtained, as they did, the amino acid with [α]D24 = -13.7° in good yield. However, in addition another α-amino-β,γ-dihydroxy-n-butyric acid, with [α]D24 = 16.0°, was isolated from the reaction mixture. It is the purpose of this communication to show that the amino acid with [α]D24 = -13.7° is not a mixture of disastereoisomers, but is D-threo-α-amino-β,γ-dihydroxy-n-butyric acid, and that the amino acid with [α]D24 = 16.0° is D-erythro-α-amino-β,γ-dihydroxy-n-butyric acid.
|Additional Information:||Copyright © 1942 by the American Society for Biochemistry and Molecular Biology. (Received for publication, December 8, 1941) We wish to thank Mr. Erik Heegaard for his assistance in connection with these experiments.|
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|Deposited On:||22 Jun 2008|
|Last Modified:||26 Dec 2012 10:07|
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