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B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits

Murre, Cornelis and Voronova, Anna and Baltimore, David (1991) B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits. Molecular and Cellular Biology, 11 (2). pp. 1156-1160. ISSN 0270-7306.

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Recent studies have identified a family of DNA-binding proteins that share a common DNA-binding and dimerization domain with the potential to form a helix-loop-helix (HLH) structure. Various HLH proteins can form heterodimers that bind to a common DNA sequence, termed the E2-box. We demonstrate here that E2-box-binding B-cell- and myocyte-specific nuclear factors contain subunits which are identical or closely related to ubiquitously expressed (E12/E47) HLH proteins. These biochemical function for E12/E47-like molecules in mammalian differentiation, similar to the genetically defined function of daughterless in Drosophila development.

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Additional Information:Copyright © 1991 by the American Society for Microbiology. Received 6 September 1990/Accepted 21 November 1990. We thank Astar Winoto, Stephen Smale, and Patrick Matthias for generously providing nuclear extracts and Helen Blau for C2C12 cells. C.M. was supported by a fellowship from the Leukemia Society of America. A.V. was supported by a fellowship from the American Cancer Society. This work was supported by Public Health Service grant GM39458.
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Deposited On:22 Jun 2008
Last Modified:26 Dec 2012 10:07

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