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Inhibition of Carboxylase by Thiazole Pyrophosphate

Buchman, Edwin R. and Heegaard, Erik and Bonner, James (1940) Inhibition of Carboxylase by Thiazole Pyrophosphate. Proceedings of the National Academy of Sciences of the United States of America, 26 (9). pp. 561-563. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:BUCpnas40

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Abstract

In the course of investigations dealing with vitamin B1 (thiamin) analogs, and having as their goal the furtherance of our knowledge of the physiological rôle of the vitamin, we have observed that a number of substances having a structure similar to that of cocarboxylase (thiamin pyrophosphate [1]), although not themselves able to replace the latter in the enzymatic decarboxylation of pyruvic acid, are able to inhibit markedly the activity of the carboxylase system. The most active inhibitant studied is the pyrophosphoric acid ester of the thiamin thiazole moiety (the thiazole pyrophosphate portion of the cocarboxylase molecule), which will be referred to as "thiazole pyrophosphate."


Item Type:Article
Additional Information:Copyright © 1940 by the National Academy of Sciences. Communicated August 9, 1940. The authors wish to express their gratitude to the Research Corporation for financial aid and to Dr. R.T. Major of Merck and Co., Inc., for generous gifts of cocarboxylase and other chemicals.
Record Number:CaltechAUTHORS:BUCpnas40
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:BUCpnas40
Alternative URL:http://www.pnas.org/content/vol26/issue9/
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11053
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:24 Jun 2008
Last Modified:26 Dec 2012 10:08

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