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v-abl causes hematopoietic disease distinct from that caused by bcr-abl

Scott, Martin L. and Van Etten, Richard A. and Daley, George Q. and Baltimore, David (1991) v-abl causes hematopoietic disease distinct from that caused by bcr-abl. Proceedings of the National Academy of Sciences of the United States of America, 88 (15). pp. 6506-6510. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:SCOpnas91

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Abstract

v-abl, the oncogene transduced by Abelson murine leukemia virus, was first characterized by its ability to transform lymphoid cells. bcr-abl, the oncogene formed by a t(9;22) translocation thought to occur in human hematopoietic stem cells, is detectable in almost all cases of chronic myelogenous leukemia (CML), a malignancy of granulocytic cells. bcr-abl also causes a CML-like syndrome in mice whose bone-marrow cells are infected with a retrovirus transducing the gene. More recent reports have suggested that v-abl can, however, cause a disease similar to CML. We demonstrate here that v-abl, when transduced in a helper virus-containing system, causes disease similar to, but distinct from, the CML-like syndrome induced by bcr-abl. Animals whose bone marrow has been infected by v-abl virus develop modest splenomegaly, marked granulocytosis, and malignant disease of several hematopoietic cell types. Unlike animals with CML-like disease resulting from bcr-abl, the polymorphonuclear leukocytes from animals infected with a v-abl construct do not contain the v-abl provirus at a significant frequency. Histopathologic analysis also shows significant differences between the diseases caused by v-abl and bcr-abl.


Item Type:Article
Additional Information:© 1991 by the National Academy of Sciences. Contributed by David Baltimore, April 22, 1991. We gratefully acknowledge Peter Jackson and Mark Kamps for helpful discussions. This work was, in part, funded by National Institutes of Health Grant CA51462-02. M.L.S. also received support from the American Cancer Society; R.A.V. was supported during part of this work by a grant from the Lucille P. Markey Charitable Trust. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Subject Keywords:ABELSON MURINE LEUKEMIA VIRUS; BONE MARROW; CHRONIC MYELOGENOUS LEUKEMIA; LYMPHOCYTE TRANSFORMATION
Record Number:CaltechAUTHORS:SCOpnas91
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:SCOpnas91
Alternative URL:http://dx.doi.org/10.1073/pnas.88.15.6506
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11060
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Jun 2008
Last Modified:14 Nov 2014 19:20

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