CaltechAUTHORS
  A Caltech Library Service

Virus-cell interaction with a tumor-producing virus

Vogt, Marguerite and Dulbecco, Renato (1960) Virus-cell interaction with a tumor-producing virus. Proceedings of the National Academy of Sciences of the United States of America, 46 (3). pp. 365-370. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:VOGpnas60

[img]
Preview
PDF
See Usage Policy.

921Kb

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:VOGpnas60

Abstract

The polyoma(PY) virus or parotid tumor agent (1,2) -- a DNA-containing virus (3,4) -- is characterized by a duality of action: it produces neoplasias of various types in different species of rodents (5), and causes cell degeneration in mouse embryo tissue cultures (6). In the experiments to be reported here, it was possible to obtain in cellular cultures in vitro the oncogenic effect of the virus; this afforded the possibility of studying the relationship between the oncogenic and cytocidal effect of the virus. The results so far obtained reveal a situation novel in animal viruses and suggest the existence of a host-virus interaction with characteristics reminiscent of temperate bacteriophage.


Item Type:Article
Additional Information:© 1960 by the National Academy of Sciences. Communicated by George W. Beadle, January 18, 1960. Aided by grants from the National Foundation and from the American Cancer Society, Inc.
Record Number:CaltechAUTHORS:VOGpnas60
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:VOGpnas60
Alternative URL:http://www.pnas.org/cgi/reprint/46/3/365
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11071
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:28 Jun 2008
Last Modified:26 Dec 2012 10:08

Repository Staff Only: item control page