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Characterization of the transverse relaxation rates in lipid bilayers

Watnick, Paula I. and Dea, Phoebe and Chan, Sunney I. (1990) Characterization of the transverse relaxation rates in lipid bilayers. Proceedings of the National Academy of Sciences of the United States of America, 87 (6). pp. 2082-2086. ISSN 0027-8424. PMCID PMC53630. http://resolver.caltech.edu/CaltechAUTHORS:WATpnas90

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Abstract

The 2H NMR transverse relaxation rates of a deuterated phospholipid bilayer reflect slow motions in the bilayer membrane. A study of dimyristoyl lecithin specifically deuterated at several positions of the hydrocarbon chains indicates that these motions are cooperative and are confined to the hydrocarbon chains of the lipid bilayer. However, lipid head group interactions do play an important role in modulating the properties of the cooperative fluctuations of the hydrocarbon chains (director fluctuations), as evidenced by the effects of various lipid additives on the 2H NMR transverse relaxation rates of the dimyristoyl lecithin bilayer.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC53630/PubMed CentralArticle
ORCID:
AuthorORCID
Chan, Sunney I.0000-0002-5348-2723
Additional Information:© 1990 by the National Academy of Sciences. Communicated by Harden M. McConnell, December 26, 1989. We are indebted to M. Dea, H. Eckert, T. Handel, A. Nayeem, and J. Yesinowski for helpful discussions and assistance. This work was supported by Grants GM-22432 (to S.I.C.), GM-36132 (to P.D.), and RR-08101 (to P.D.) from the National Institutes of General Medical Sciences, U.S. Public Health Service; and Petroleum Research Fund Grant 20212-B4 (to P.D.) administered by the American Chemical Society. P.I.W. was a recipient of National Research Service Award T32 GM07616 from the National Institutes of General Medical Sciences. Access to the Southern California Regional NMR Facility at Caltech, supported by Grant CHE84-40137 from the National Science Foundation, for the NMR experiments is gratefully acknowledged. This is contribution 7974 from the Division of Chemistry and Chemical Engineering. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Funders:
Funding AgencyGrant Number
NIHGM-22432
NIHGM-36132
NIHRR-08101
National Institute of General Medical SciencesUNSPECIFIED
American Chemical Society Petroleum Research Fund20212-B4
NIH Predoctoral FellowshipT32 GM07616
NSFCHE84-40137
Subject Keywords:deuterium NMR, bilayer membrane, director fluctuations
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Other Numbering System NameOther Numbering System ID
Caltech Division of Chemistry and Chemical Engineering7974
PubMed Central ID:PMC53630
Record Number:CaltechAUTHORS:WATpnas90
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:WATpnas90
Alternative URL:http://www.pnas.org/cgi/content/abstract/87/6/2082
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1108
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Dec 2005
Last Modified:22 Sep 2017 04:56

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