Farnsworth, V. and Goodfliesh, R. and Rodkey, S. and Hood, L. (1976) Immunoglobulin allotypes of rabbit kappa chains: Polymorphism of a control mechanism regulating closely linked duplicated genes? Proceedings of the National Academy of Sciences of the United States of America, 73 (4). pp. 1293-1296. ISSN 0027-8424 http://resolver.caltech.edu/CaltechAUTHORS:FARpnas76
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The amino acid sequence of the constant (CK) region from the kappa immunoglobulin chains of a b9 rabbit is compared with the CK sequences, taken from the literature, of a b4 rabbit. These CK regions differ by 33% of their amino acid sequences and by three sequence insertions or deletions (sequence gaps). These extensive differences together with other published observations suggest that the b9 and b4 CK genes may not be simple alleles, but rather they may be encoded by closely linked CK genes present in every rabbit whose expression is regulated by a polymorphic control mechanism.
|Additional Information:||© 1976 by the National Academy of Sciences. Communicated by Henry C. Kunkel, January 9, 1976. This work was carried out under grants from the National Science Foundation and the National Institutes of Health. R.G. has an NIH Postdoctoral Fellowship. L.H. has an NIH Research Career Development Award. This paper is contribution 1267, Division of Biology, Kansas Agricultural Experiment Station, Kansas State University, Manhattan, Kans. 66506.|
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|Deposited By:||Tony Diaz|
|Deposited On:||16 Jul 2008 19:59|
|Last Modified:||26 Dec 2012 10:08|
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