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Immunoglobulin allotypes of rabbit kappa chains: Polymorphism of a control mechanism regulating closely linked duplicated genes?

Farnsworth, V. and Goodfliesh, R. and Rodkey, S. and Hood, L. (1976) Immunoglobulin allotypes of rabbit kappa chains: Polymorphism of a control mechanism regulating closely linked duplicated genes? Proceedings of the National Academy of Sciences of the United States of America, 73 (4). pp. 1293-1296. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:FARpnas76

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Abstract

The amino acid sequence of the constant (CK) region from the kappa immunoglobulin chains of a b9 rabbit is compared with the CK sequences, taken from the literature, of a b4 rabbit. These CK regions differ by 33% of their amino acid sequences and by three sequence insertions or deletions (sequence gaps). These extensive differences together with other published observations suggest that the b9 and b4 CK genes may not be simple alleles, but rather they may be encoded by closely linked CK genes present in every rabbit whose expression is regulated by a polymorphic control mechanism.


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http://www.pnas.org/content/73/4/1293.abstractPublisherUNSPECIFIED
Additional Information:© 1976 by the National Academy of Sciences. Communicated by Henry C. Kunkel, January 9, 1976. This work was carried out under grants from the National Science Foundation and the National Institutes of Health. R.G. has an NIH Postdoctoral Fellowship. L.H. has an NIH Research Career Development Award. This paper is contribution 1267, Division of Biology, Kansas Agricultural Experiment Station, Kansas State University, Manhattan, Kans. 66506.
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National Science FoundationUNSPECIFIED
National Institutes of Health Postdoctoral FellowshipUNSPECIFIED
National Institutes of Health Rsearch Career Development AwardUNSPECIFIED
Record Number:CaltechAUTHORS:FARpnas76
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:FARpnas76
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11083
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:16 Jul 2008 19:59
Last Modified:26 Dec 2012 10:08

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