Einhäuser, Wolfgang and Stout, James and Koch, Christof and Carter, Olivia (2008) Pupil dilation reflects perceptual selection and predicts subsequent stability in perceptual rivalry. Proceedings of the National Academy of Sciences of the United States of America, 105 (5). pp. 1704-1709. ISSN 0027-8424 http://resolver.caltech.edu/CaltechAUTHORS:EINpnas08
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Abstract
During sustained viewing of an ambiguous stimulus, an individual's perceptual experience will generally switch between the different possible alternatives rather than stay fixed on one interpretation (perceptual rivalry). Here, we measured pupil diameter while subjects viewed different ambiguous visual and auditory stimuli. For all stimuli tested, pupil diameter increased just before the reported perceptual switch and the relative amount of dilation before this switch was a significant predictor of the subsequent duration of perceptual stability. These results could not be explained by blink or eye-movement effects, the motor response or stimulus driven changes in retinal input. Because pupil dilation reflects levels of norepinephrine (NE) released from the locus coeruleus (LC), we interpret these results as suggestive that the LC–NE complex may play the same role in perceptual selection as in behavioral decision making.
| Item Type: | Article | ||||||||||||||
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| Additional Information: | © 2008 by The National Academy of Sciences of the USA. Edited by Dale Purves, Duke University Medical Center, Durham, NC, and approved December 18, 2007 (received for review August 16, 2007). Published online before print February 4, 2008, doi: 10.1073/pnas.0707727105. This article is a PNAS Direct Submission. The work was supported by Swiss National Science Foundation Grant PA00A-111447 (to W.E.); the Defense Advanced Research Planning Agency/National Geospatial Intelligence Agency; the National Science Foundation; the National Institute of Mental Health; and the National Health and Medical Research Council (Australia) C.J. Martin Fellowship 368525 (to O.C.). Author contributions: W.E. and O.C. designed research; W.E., J.S., and C.K. performed research; C.K. contributed new reagents/analytic tools; W.E. analyzed data; and W.E. and O.C. wrote the paper. The authors declare no conflict of interest. This article contains supporting information online at www.pnas.org/cgi/content/full/0707727105/DC1. See also: Wolfgang Einhäuser, James Stout, Christof Koch, and Olivia Carter. Reply to Hupé et al.: The predictive correlation of pupil dilation and relative dominance durations in rivalry is not a statistical artifact. PNAS 105(28):E44 doi:10.1073/pnas.0803927105 | ||||||||||||||
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| Subject Keywords: | attention; norepinephrine; vision; decision making | ||||||||||||||
| Record Number: | CaltechAUTHORS:EINpnas08 | ||||||||||||||
| Persistent URL: | http://resolver.caltech.edu/CaltechAUTHORS:EINpnas08 | ||||||||||||||
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| Official Citation: | Wolfgang Einhäuser, James Stout, Christof Koch, and Olivia Carter. From the Cover: Pupil dilation reflects perceptual selection and predicts subsequent stability in perceptual rivalryPNAS 2008 105:1704-1709; published online before print February 4, 2008, doi:10.1073/pnas.0707727105 | ||||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||
| ID Code: | 11169 | ||||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||||
| Deposited By: | Archive Administrator | ||||||||||||||
| Deposited On: | 21 Jul 2008 23:02 | ||||||||||||||
| Last Modified: | 26 Dec 2012 10:10 |
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