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Logic functions of the genomic cis-regulatory code

Istrail, Sorin and Davidson, Eric H. (2005) Logic functions of the genomic cis-regulatory code. Proceedings of the National Academy of Sciences of the United States of America, 102 (14). pp. 4954-4959. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:ISTpnas05

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Abstract

cis-regulatory modules that control developmental gene expression process the regulatory inputs provided by the transcription factors for which they contain specific target sites. A prominent class of cis-regulatory processing functions can be modeled as logic operations. Many of these are combinatorial because they are mediated by multiple sites, although others are unitary. In this work, we illustrate the repertoire of cis-regulatory logic operations, as an approach toward a functional interpretation of the genomic regulatory code.


Item Type:Article
Additional Information:Copyright © 2005 by the National Academy of Sciences. Contributed by Eric H. Davidson, December 22, 2004. This work was supported by a grant from Applied Biosystems/Celera Genomics (to S.I.) and by U.S. Department of Energy Grant DE-FG02-03ER63584 (to E H.D.).
Subject Keywords:SEA-URCHIN EMBRYO, DROSOPHILA EMBRYO, BITHORAX COMPLEX, RANGE REPRESSION, GENE-REGULATION, ENDO16 GENE, NETWORK, SPECIFICATION, ORGANIZATION, SITES
Record Number:CaltechAUTHORS:ISTpnas05
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:ISTpnas05
Alternative URL:http://dx.doi.org/10.1073/pnas.0409624102
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1164
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:29 Dec 2005
Last Modified:26 Dec 2012 08:43

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