Istrail, Sorin and Davidson, Eric H. (2005) Logic functions of the genomic cis-regulatory code. Proceedings of the National Academy of Sciences of the United States of America, 102 (14). pp. 4954-4959. ISSN 0027-8424. PMCID PMC555989. http://resolver.caltech.edu/CaltechAUTHORS:ISTpnas05
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cis-regulatory modules that control developmental gene expression process the regulatory inputs provided by the transcription factors for which they contain specific target sites. A prominent class of cis-regulatory processing functions can be modeled as logic operations. Many of these are combinatorial because they are mediated by multiple sites, although others are unitary. In this work, we illustrate the repertoire of cis-regulatory logic operations, as an approach toward a functional interpretation of the genomic regulatory code.
|Additional Information:||Copyright © 2005 by the National Academy of Sciences. Contributed by Eric H. Davidson, December 22, 2004. This work was supported by a grant from Applied Biosystems/Celera Genomics (to S.I.) and by U.S. Department of Energy Grant DE-FG02-03ER63584 (to E H.D.).|
|Subject Keywords:||SEA-URCHIN EMBRYO, DROSOPHILA EMBRYO, BITHORAX COMPLEX, RANGE REPRESSION, GENE-REGULATION, ENDO16 GENE, NETWORK, SPECIFICATION, ORGANIZATION, SITES|
|PubMed Central ID:||PMC555989|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||29 Dec 2005|
|Last Modified:||23 Dec 2015 23:57|
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