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Transcriptional network underlying Caenorhabditis elegans vulval development

Inoue, Takao and Wang, Minqin and Ririe, Ted O. and Fernandes, Jolene S. and Sternberg, Paul W. (2005) Transcriptional network underlying Caenorhabditis elegans vulval development. Proceedings of the National Academy of Sciences of the United States of America, 102 (14). pp. 4972-4977. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:INOpnas05

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Abstract

The vulval development of Caenorhabditis elegans provides an opportunity to investigate genetic networks that control gene expression during organogenesis. During the fourth larval stage (L4), seven vulval cell types are produced, each of which executes a distinct gene expression program. We analyze how the expression of cell-type-specific genes is regulated. Ras and Writ signaling pathways play major roles in generating the spatial pattern of cell types and regulate gene expression through a network of transcription factors. One transcription factor (lin-29) primarily controls the temporal expression pattern. Other transcription factors (lin-11, cog-1, and egl-38) act in combination to control cell-type-specific gene expression. The complexity of the network arises in part because of the dynamic nature of gene expression, in part because of the presence of seven cell types, and also because there are multiple regulatory paths for gene expression within each cell type.


Item Type:Article
Additional Information:Copyright © 2005 by the National Academy of Sciences. Edited by Eric H. Davidson, California Institute of Technology, Pasadena, CA, and approved February 1, 2005 (received for review November 11, 2004). We thank A. Fire (Stanford University, Stanford, CA) for providing GFP vectors, and I. Hope (University of Leeds, Leeds, U.K.) for providing the C55C3.5::gfp construct. We thank Ryan Baugh, Jennifer Sanders, Mihoko Kato, Steven Kuntz, Alok Saldanha, and reviewers for comments on the manuscript. We thank the Caenorhabditis Genetics Center (University of Minnesota, Minneapolis) for C. elegans strains. T.I. was supported by fellowship DRG-1646 from the Damon Runyon Cancer Research Foundation. Research was supported by the Howard Hughes Medical Institute, with which P.W.S. is an investigator. This paper was submitted directly (Track II) to the PNAS office.
Subject Keywords:ORGANOGENESIS, SIGNALING PATHWAYS, TRANSCRIPTION, HOMEOBOX GENE LIN-11, VENTRAL NEURAL-TUBE, C-ELEGANS, CELL MORPHOGENESIS, NEURONAL FATE, PROTEIN, ENCODES, DIFFERENTIATION, HOMEODOMAIN, EXPRESSION
Record Number:CaltechAUTHORS:INOpnas05
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:INOpnas05
Alternative URL:http://dx.doi.org/10.1073/pnas.0408122102
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1165
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:29 Dec 2005
Last Modified:14 Nov 2014 19:18

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