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Alpha-aminoadipic acid: A product of lysine metabolism

Borsook, Henry and Deasy, Clara L. and Haagen-Smit, A. J. and Keighley, Geoffrey and Lowy, Peter H. (1948) Alpha-aminoadipic acid: A product of lysine metabolism. Journal of Biological Chemistry, 173 (1). pp. 423-424. ISSN 0021-9258.

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As part of a study of protein and peptide metabolism lysine was synthesized with C14 in the ε position and resolved into the L and D isomers. 10 mg. of labeled lysine dihydrochloride (either L- or D-) and 0.66 gm. (wet weight) of guinea pig liver homogenate were added to a reaction mixture containing 1.3 per cent of an amino acid mixture corresponding to the composition of casein except for lysine and 0.01 M α-ketoglutarate, all in a final volume of 4 ml. of isotonic saline solution.(1) The reaction was carried out under oxygen for 6 hours at 38°.

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Additional Information:© 1948 American Society of Biological Chemists. Received for publication, January 17, 1948. This work is a part of that done under contract with the Office of Naval Research, United States Navy Department.
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Office of Naval ResearchUNSPECIFIED
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11784
Deposited By: Tony Diaz
Deposited On:02 Oct 2008 01:37
Last Modified:26 Dec 2012 10:20

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