Borsook, Henry and Deasy, Clara L. and Haagen-Smit, A. J. and Keighley, Geoffrey and Lowy, Peter H. (1948) The degradation of L-lysine in guinea pig liver homogenate: formation of alpha-aminoadipic acid. Journal of Biological Chemistry, 176 (3). pp. 1383-1393. ISSN 0021-9258 http://resolver.caltech.edu/CaltechAUTHORS:BORjbc48c
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A summary of the little that is known of the metabolism of lysine in animals is as follows: it is indispensable in the diet, its α-amino group does not participate in reversible transamination reaction in vivo (2), neither the L nor D form is attacked by the appropriate amino acid oxidase, certain ε-nitrogen-substituted derivatives can replace lysine in the diet and their α-amino groups are oxidized by amino acid oxidases (3, 4), no α-nitrogen-substituted derivatives yet prepared can substitute for lysine in the diet (4-6).
|Additional Information:||© 1948 American Society of Biological Chemists. Received for publication, June 21, 1948. The authors were assisted by A. A. Dvorsky, D. Eggarter, H. E. Jeffery, G. Oppenheimer, and A. Tollestrup. This work is a part of that done under contract with the Office of Naval Research, United States Navy Department. A summary of this work has been reported (1). The C14 used in this investigation was supplied by the Monsanto Chemical Company, Clinton Laboratories, Oak Ridge, Tennessee, and obtained on allocation from the United States Atomic Energy Commission.|
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|Deposited By:||Tony Diaz|
|Deposited On:||03 Oct 2008 18:56|
|Last Modified:||26 Dec 2012 10:20|
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