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Incorporation in vitro of labeled amino acids into bone marrow cell proteins

Borsook, Henry and Deasy, Clara L. and Haagen-Smit, A. J. and Keighley, Geoffrey and Lowy, Peter H. (1950) Incorporation in vitro of labeled amino acids into bone marrow cell proteins. Journal of Biological Chemistry, 186 (1). pp. 297-307. ISSN 0021-9258. http://resolver.caltech.edu/CaltechAUTHORS:BORjbc50c

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Abstract

Nearly all experiments on the incorporation of labeled amino acids into tissue proteins in vitro have been done on tissues whose cell structure has been partially or completely disintegrated, e.g. tissue slices, segments, or homogenates. Since cell destruction reduces or abolishes the uptake of labeled amino acids (1), it seemed worth while to carry out studies on intact cells in vitro. Bone marrow cells were found to be suitable for this purpose. The labeled amino acids used were glycine-1-C14, L-leucine-1-C14, L-lysine-1-C14, and L-lysine-6-C14.


Item Type:Article
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http://www.jbc.org/content/vol186/issue1/index.shtmlPublisherUNSPECIFIED
Additional Information:© 1950 American Society of Biological Chemists. Received for publication, February 25, 1950. This work was carried out under the joint sponsorship of the United States Atomic Energy Commission and the Office of Naval Research. The C14 used was supplied by the Carbide and Carbon Chemicals Corp., Oak Ridge, Tennessee, and obtained on allocation from the United States Atomic Energy Commission.
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Funding AgencyGrant Number
Atomic Energy CommissionUNSPECIFIED
Office of Naval ResearchUNSPECIFIED
Record Number:CaltechAUTHORS:BORjbc50c
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:BORjbc50c
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11822
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 Oct 2008 22:30
Last Modified:26 Dec 2012 10:21

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