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Growth inhibition of neurospora by canavanine, and its reversal

Horowitz, N. H. and Srb, Adrian M. (1948) Growth inhibition of neurospora by canavanine, and its reversal. Journal of Biological Chemistry, 174 (1). pp. 371-378. ISSN 0021-9258. http://resolver.caltech.edu/CaltechAUTHORS:HORjbc48

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Abstract

Canavanine, an amino acid from jack beans, was discovered by Kitagawa and coworkers in 1929 (1, 2). The substance is not combined in the proteins of the seed, but occurs in the free state, and makes up 2.5 per cent of the dry weight of jack beans (3). In a series of papers available to the authors for the most part in abstract only, the Japanese workers have reported extensive investigations into the chemistry and physiology of the substance. The structure of canavanine was established by Gulland and Morris (4) and by Kitagawa and Takani (5) as NH2•C(:NII)•NII•O•CH2•CH2•CHNH2•COOH. Natural canavanine is of the L configuration (6).


Item Type:Article
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http://www.jbc.org/cgi/reprint/174/1/371PublisherUNSPECIFIED
Additional Information:© 1948 American Society of Biological Chemists. Received for publication, February 4, 1948. We wish to thank Dr. G. Oppenheimer and Dr. A. J. Haagen-Smit for the microanalyses of C, H, and N. This investigation was supported by the Rockefeller Foundation and the Nutrition Foundation, Inc. [A.M.S. was a]National Research Council Fellow, 1946-47.
Funders:
Funding AgencyGrant Number
Rockefeller FoundationUNSPECIFIED
Nutrition Foundation, Inc.UNSPECIFIED
National Researh CouncilUNSPECIFIED
Record Number:CaltechAUTHORS:HORjbc48
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:HORjbc48
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11857
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:10 Oct 2008 03:52
Last Modified:26 Dec 2012 10:22

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