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Slow synaptic transmission in frog sympathetic ganglia

Adams, P. R. and Jones, S. W. and Pennefeather, P. and Brown, D. A. and Koch, Christof and Lancaster, B. (1986) Slow synaptic transmission in frog sympathetic ganglia. Journal of Experimental Biology, 124 . pp. 259-285. ISSN 0022-0949. PMCID 3020147. http://resolver.caltech.edu/CaltechAUTHORS:ADAjeb86

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Abstract

Bullfrog ganglia contain two classes of neurone, B and C cells, which receive different inputs and exhibit different slow synaptic potentials. B cells, to which most effort has been directed, possess slow and late slow EPSPs. The sEPSP reflects a muscarinic action of acetylcholine released from boutons on B cells, whereas the late sEPSP is caused by a peptide (similar to teleost LHRH) released from boutons on C cells. During either sEPSP there is a selective reduction in two slow potassium conductances, designated 'M' and 'AHP'. The M conductance is voltage dependent and the AHP conductance is calcium dependent. Normally they act synergistically to prevent repetitive firing of action potentials during maintained stimuli. Computer stimulation of the interactions of these conductances with the other five voltage-dependent conductances present in the membrane allows a complete reconstruction of the effects of slow synaptic transmission on electrical behaviour.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://jeb.biologists.org/cgi/content/abstract/124/1/259PublisherUNSPECIFIED
http://www.ncbi.nlm.nih.gov/pubmed/3020147PubMed Central IDPubMed Article
Additional Information:Copyright © 1986 by Company of Biologists. This work was supported by NIH grants NS 18579 (PRA) and NS 20751 (SWJ). The manuscript was prepared during a visit to the Instituto de Investigaciones Bioquimicas, Bahia Blanca, supported by the CONICET of Argentina. PRA thanks F. J. Barrantes for his hospitality and M. H. Salaberry de Saint-Lary and L. Nielsen for their help with the manuscript. Further help was provided by Dahl Capello.
Group:Koch Laboratory, KLAB
Funders:
Funding AgencyGrant Number
National Institutes of HealthNS 18579
National Institutes of HealthNS 20751
CONICET (Argentina)UNSPECIFIED
Subject Keywords:sympathetic ganglion, slow EPSP, muscarinic receptor
PubMed Central ID:3020147
Record Number:CaltechAUTHORS:ADAjeb86
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:ADAjeb86
PubMed Central ID:3020147
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11999
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:16 Oct 2008 23:56
Last Modified:08 Oct 2013 16:11

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