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Expression of baculovirus P35 prevents cell death in Drosophila

Hay, Bruce A. and Wolff, Tanya and Rubin, Gerald M. (1994) Expression of baculovirus P35 prevents cell death in Drosophila. Development, 120 (8). pp. 2121-2129. ISSN 0950-1991. http://resolver.caltech.edu/CaltechAUTHORS:HAYdev94

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Abstract

The baculovirus P35 protein functions to prevent apoptotic death of infected cells. We have expressed P35 in the developing embryo and eye of the fly Drosophila melanogaster. P35 eliminates most, if not all, normally occurring cell death in these tissues, as well as X-irradiation-induced death. Excess pupal eye cells that are normally eliminated by apoptosis develop into pigment cells when their death is prevented by P35 expression. Our results suggest that one mechanism by which viruses prevent the death of the host cell is to block a cell death pathway that mediates normally occurring cell death. Identification of molecules that interact biochemically or genetically with P35 in Drosophila should provide important insights into how cell death is regulated.


Item Type:Article
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http://dev.biologists.org/cgi/content/abstract/120/8/2121PublisherUNSPECIFIED
Additional Information:Copyright © 1994 by Company of Biologists. (Accepted 25 April 1994) We would like to thank Lois K. Miller for providing the plasmid containing P35, Ross Cagan for providing the enhancer trap line LE07 and Mike Ellis and Betsy O’Neill for discussions concerning the expression of glass and manipulation of the multimerized glass-binding sites. We would also like to thank Ross Cagan, Donald Ready and Yuh Nung Jan for useful comments on the manuscript and Wilfred Bentham for assistance with scanning electron microscopy. This work has been supported by the Helen Hay Whitney Foundation (B.A.H.) and the American Cancer Society (T.W.); G.M.R. is a Howard Hughes Medical Institute investigator.
Funders:
Funding AgencyGrant Number
Helen Hay Whitney FoundationUNSPECIFIED
American Cancer SocietyUNSPECIFIED
Howard Hughes Medical InstituteUNSPECIFIED
Subject Keywords:baculovirus, P35, cell death, Drosophila
Record Number:CaltechAUTHORS:HAYdev94
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:HAYdev94
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:12197
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:28 Oct 2008 22:43
Last Modified:26 Dec 2012 10:28

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