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Two distinct inputs to an avian song nucleus activate different glutamate receptor subtypes on individual neurons

Mooney, Richard and Konishi, Masakazu (1991) Two distinct inputs to an avian song nucleus activate different glutamate receptor subtypes on individual neurons. Proceedings of the National Academy of Sciences of the United States of America, 88 (10). pp. 4075-4079. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:MOOpnas91

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Abstract

Although neural circuits mediating various simple behaviors have been delineated, those generating more complex behaviors are less well described. The discrete structure of avian song control nuclei promises that circuits controlling complex behaviors, such as birdsong, can also be understood. To this end, we developed an in vitro brain slice preparation containing the robust nucleus of the archistriatum (RA), a forebrain song control nucleus, and its inputs from two other song nuclei, the caudal nucleus of the ventral hyperstriatum (HVc) and the lateral part of the magnocellular nucleus of the anterior neostriatum (L-MAN). Using intracellular recordings, we examined the pharmacological properties of the synapses made on RA neurons by L-MAN and HVc axons. Electrical stimulation of the L-MAN and the HVc fiber tracts evoked excitatory postsynaptic potentials (EPSPs) from > 70% of RA neurons when slices were prepared from male birds of 40-90 days of age, suggesting that many individual RA neurons receive excitatory input from L-MAN and HVc axons. The "L-MAN" EPSPs were blocked by the N-methyl-D-aspartate (NMDA) receptor antagonist D-(-)-2-amino-5-phosphonovaleric acid (D-APV) as well as the broad-spectrum glutamate receptor antagonist kynurenic acid but were relatively unaffected by the non-NMDA receptor blocker 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). In contrast, "HVc" EPSPs were relatively insensitive to D-APV but almost completely abolished by CNQX. These experiments suggest that L-MAN and HVc axons provide pharmacologically distinct types of excitatory input to many of the same RA neurons.


Item Type:Article
Additional Information:Copyright © 1991 by the National Academy of Sciences. Contributed by Masakazu Konishi, January 23, 1991. We thank Dr. Gilles Laurent for reading the manuscript. This work was supported by a grant from the McKnight Foundation. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Subject Keywords:N-METHYL-D-ASPARTATE, EXCITATORY POSTSYNAPTIC POTENTIALS, BIRDSONG, LAMPREY SPINAL-CORD, ZEBRA FINCH SONG, FICTIVE LOCOMOTION, FOREBRAIN NUCLEUS, ACID, CANARY, CONNECTIONS, ANTAGONISTS, LESIONS, SYSTEM
Record Number:CaltechAUTHORS:MOOpnas91
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:MOOpnas91
Alternative URL:http://www.pnas.org/cgi/content/abstract/88/10/4075
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1224
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 Jan 2006
Last Modified:26 Dec 2012 08:43

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