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Dunce mutants of Drosophila melanogaster: mutants defective in the cyclic AMP phosphodiesterase enzyme system

Davis, Ronald L. and Kiger, John A., Jr. (1981) Dunce mutants of Drosophila melanogaster: mutants defective in the cyclic AMP phosphodiesterase enzyme system. Journal of Cell Biology, 90 (1). pp. 101-107. ISSN 0021-9525. http://resolver.caltech.edu/CaltechAUTHORS:DAVjcb81

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Abstract

The cyclic AMP and cyclic GMP phosphodiesterase activities present in flies of six mutant strains of the dunce gene and in the parent wild- type strains are characterized. All of the mutants exhibit aberrant cyclic AMP metabolism. The mutant strains dunceM14, dunceM11, and dunceML appear to be amorphic, because they completely lack the cAMP-specific phosphodiesterase normally present in adult flies. These strains exhibit extremely high levels of cAMP. The mutant strains dunce1, dunce2, and dunceCK are hypomorphic and exhibit reduced levels of the cAMP-specific phosphodiesterase. These strains exhibit less marked increases in cAMP content compared with the three amorphic strains. The dunce2 strain possesses a residual enzyme activity that exhibits anomalous kinetics compared with those of the normal enzyme. The possibility that the dunce locus is the structural gene for the cAMP-specific phosphodiesterase is discussed.


Item Type:Article
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http://jcb.rupress.org/cgi/content/abstract/90/1/101PublisherUNSPECIFIED
Additional Information:© 1981 Rockefeller University Press. RUP grants the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode. Received for publication 2 September 1980, and in revised form 5 March 1981. This work was supported by grants GM 21137 and GM 07467 from The U.S. Public Health Service; R.L. Davis was a predoctoral National Institutes of Health Trainee.
Funders:
Funding AgencyGrant Number
Public Health ServiceGM 21137
Public Health ServiceGM 07467
Record Number:CaltechAUTHORS:DAVjcb81
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:DAVjcb81
Usage Policy:RUP grants the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode.
ID Code:12296
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Nov 2008 22:55
Last Modified:26 Dec 2012 10:29

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