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CLAVATA3 is a specific regulator of shoot and floral meristem development affecting the same processes as CLAVATA1

Clark, Steven M. and Running, Mark P. and Meyerowitz, Elliot M. (1995) CLAVATA3 is a specific regulator of shoot and floral meristem development affecting the same processes as CLAVATA1. Development, 121 (7). pp. 2057-2067. ISSN 0950-1991.

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We have previously described the phenotype of Arabidopsis thaliana plants with mutations at the CLAVATA1 (CLV1) locus (Clark, S. E., Running, M. P. and Meyerowitz, E. M. (1993) Development 119, 397-418). Our investigations demonstrated that clv1 plants develop enlarged vegetative and inflorescence apical meristems, and enlarged and indeterminate floral meristems. Here, we present an analysis of mutations at a separate locus, CLAVATA3(CLV3), that disrupt meristem development in a manner similar to clv1mutations. clv3 plants develop enlarged apical meristems as early as the mature embryo stage. clv3 floral meristems are also enlarged compared with wild type, and maintain a proliferating meristem throughout flower development. clv3 root meristems are unaffected, indicating that CLV3 is a specific regulator of shoot and floral meristem development. We demonstrate that the strong clv3-2 mutant is largely epistatic to clv1 mutants, and that the semi-dominance of clv1 alleles is enhanced by double heterozygosity with clv3 alleles, suggesting that these genes work in the same pathway to control meristem development. We propose that CLV1 and CLV3 are required to promote the differentiation of cells at the shoot and floral meristem.

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Additional Information:© The Company of Biologists Limited 1995. (Accepted 22 March 1995) We thank our colleagues in the Meyerowitz lab for critical review of this manuscript. We also thank Pat Koen of the Electron Microscope Facility at Caltech for technical advice. A special note of appreciation goes to David Smyth for providing clv3-1 and clv3-2 mutants. This material is based on work supported by the National Science Foundation under Grant No. MCB-9204839 to E.M.M. and a Postdoctoral Fellowship in Plant Biology to S.E.C. This work was also supported by a grant from the Strategic Research Fund of Zeneca Seeds to E.M.M. and a Zeneca Fellowship to S.E.C. M.P.R. was a Howard Hughes Predoctoral Fellow.
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National Science FoundationMCB-9204839
Howard Hughes Medical InstituteUNSPECIFIED
Subject Keywords:organogenesis, pattern formation, cell division, cell differentiation, Arabidopsis, CLAVATA3, shoot meristem
Record Number:CaltechAUTHORS:CLAdev95
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:12475
Deposited By: Arun Sannuti
Deposited On:05 Dec 2008 21:39
Last Modified:26 Dec 2012 10:32

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