Cohen, Donald S. and Erneux, Thomas (1988) Free boundary problems in controlled release pharmaceuticals: II. swelling-controlled release. SIAM Journal on Applied Mathematics, 48 (6). pp. 1466-1474. ISSN 0036-1399. http://resolver.caltech.edu/CaltechAUTHORS:COHsiamjam88b
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A problem in controlled release pharmaceutical systems is formulated and studied. The device modeled is a polymer matrix containing an initially immobilized drug. The release of the drug is achieved by countercurrent diffusion through a penetrant solvent with the release rate being determined by the rate of diffusion of the solvent in the polymer. The mathematical theory yields a free boundary problem which is studied in various asymptotic regimes.
|Additional Information:||©1988 Society for Industrial and Applied Mathematics. Received by the editors September 10, 1986; accepted for publication (in revised form) September 16, 1987. [D.S.C] was supported in part by U.S. Army Research Office (Durham) under contract DAAG29-85-K-0092, by the National Science Foundation under grant DMS-8706642, and by the Department of Energy under grant 7405/ENG-36 at the Center for Nonlinear Studies at Los Alamos. [T.E] was supported in part by the Air Force Office of Scientific Research under grant AFOSR85-0150 and the National Science Foundation under grant DMS-8701302.|
|Subject Keywords:||free boundaries; perturbations; polymers; controlled release|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Kristin Buxton|
|Deposited On:||24 Dec 2008 00:00|
|Last Modified:||26 Dec 2012 10:38|
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