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Distinct roles of transcription factors EGL-46 and DAF-19 in specifying the functionality of a polycystin-expressing sensory neuron necessary for C. elegans male vulva location behavior

Yu, Hui and Prétôt, René F. and Bürglin, Thomas R. and Sternberg, Paul W. (2003) Distinct roles of transcription factors EGL-46 and DAF-19 in specifying the functionality of a polycystin-expressing sensory neuron necessary for C. elegans male vulva location behavior. Development, 130 (21). pp. 5217-5227. ISSN 0950-1991. http://resolver.caltech.edu/CaltechAUTHORS:YUHdev03

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Abstract

Caenorhabditis elegans polycystins LOV-1 and PKD-2 are expressed in the male-specific HOB neuron, and are necessary for sensation of the hermaphrodite vulva during mating. We demonstrate that male vulva location behavior and expression of lov-1 and pkd-2 in the ciliated sensory neuron HOB require the activities of transcription factor EGL-46 and to some extent also EGL-44. This EGL-46- regulated program is specific to HOB and is distinct from a general ciliogenic pathway functioning in all ciliated neurons. The ciliogenic pathway regulator DAF-19 affects downstream components of the HOB-specific program indirectly and is independent of EGL-46 activity. The sensory function of HOB requires the combined action of these two distinct regulatory pathways.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1242/dev.00678DOIUNSPECIFIED
http://dev.biologists.org/cgi/content/abstract/130/21/5217PublisherUNSPECIFIED
Additional Information:Copyright © 2003 The Company of Biologists Limited. Accepted 19 June 2003. First published online 3 September 2003. We thank Ji Wu, Martin Chalfie, Peter Swoboda, Maureen Barr, Hillel Schwartz, H. Robert Horvitz, Ann Hart and Joan Collet for GFP, CFP, and YFP plasmids and strains. We thank Alan Coulson for providing cosmids, the Caenorhabditis Genetic Center for providing some strains used in this study, and the C. elegans Genome Sequencing Consortium and WormBase for sequence information. We thank L. Rene Garcia, Takao Inoue, Gary Schindelman, Allyson Whittaker and X.Z. Shawn Xu for helpful discussions and critical reading of this manuscript. This work was supported by USPHS grant #1P50DK57325 to G. Germino (co-PI, P.W.S.). P.W.S. is an Investigator with the HHMI. H.Y. was a recipient of a Gordon Ross graduate fellowship. R.F.P. and T.R.B. were supported by grants from the Swiss National Science Foundation. T.R.B. was recipient of a START Fellowship (NF. 3130-038786.93) and is now supported by the Swedish Foundation for Strategic Research (SSF).
Funders:
Funding AgencyGrant Number
Public Health Service1P50DK57325
Howard Hughes Medical InstituteUNSPECIFIED
Gordon Ross Medical FoundationUNSPECIFIED
Swiss National Science FoundationNF. 3130-038786.93
Swedish Foundation for Strategic Research (SSF)UNSPECIFIED
Subject Keywords:Transcriptional regulation, Cell specification, Zinc finger proteins, TEF, RFX factors, Polycystins
Record Number:CaltechAUTHORS:YUHdev03
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:YUHdev03
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:12708
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:21 Dec 2008 01:29
Last Modified:26 Dec 2012 10:39

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