Yu, Hui and Prétôt, René F. and Bürglin, Thomas R. and Sternberg, Paul W. (2003) Distinct roles of transcription factors EGL-46 and DAF-19 in specifying the functionality of a polycystin-expressing sensory neuron necessary for C. elegans male vulva location behavior. Development, 130 (21). pp. 5217-5227. ISSN 0950-1991 http://resolver.caltech.edu/CaltechAUTHORS:YUHdev03
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Caenorhabditis elegans polycystins LOV-1 and PKD-2 are expressed in the male-specific HOB neuron, and are necessary for sensation of the hermaphrodite vulva during mating. We demonstrate that male vulva location behavior and expression of lov-1 and pkd-2 in the ciliated sensory neuron HOB require the activities of transcription factor EGL-46 and to some extent also EGL-44. This EGL-46- regulated program is specific to HOB and is distinct from a general ciliogenic pathway functioning in all ciliated neurons. The ciliogenic pathway regulator DAF-19 affects downstream components of the HOB-specific program indirectly and is independent of EGL-46 activity. The sensory function of HOB requires the combined action of these two distinct regulatory pathways.
|Additional Information:||Copyright © 2003 The Company of Biologists Limited. Accepted 19 June 2003. First published online 3 September 2003. We thank Ji Wu, Martin Chalfie, Peter Swoboda, Maureen Barr, Hillel Schwartz, H. Robert Horvitz, Ann Hart and Joan Collet for GFP, CFP, and YFP plasmids and strains. We thank Alan Coulson for providing cosmids, the Caenorhabditis Genetic Center for providing some strains used in this study, and the C. elegans Genome Sequencing Consortium and WormBase for sequence information. We thank L. Rene Garcia, Takao Inoue, Gary Schindelman, Allyson Whittaker and X.Z. Shawn Xu for helpful discussions and critical reading of this manuscript. This work was supported by USPHS grant #1P50DK57325 to G. Germino (co-PI, P.W.S.). P.W.S. is an Investigator with the HHMI. H.Y. was a recipient of a Gordon Ross graduate fellowship. R.F.P. and T.R.B. were supported by grants from the Swiss National Science Foundation. T.R.B. was recipient of a START Fellowship (NF. 3130-038786.93) and is now supported by the Swedish Foundation for Strategic Research (SSF).|
|Subject Keywords:||Transcriptional regulation, Cell specification, Zinc finger proteins, TEF, RFX factors, Polycystins|
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|Deposited By:||Archive Administrator|
|Deposited On:||21 Dec 2008 01:29|
|Last Modified:||26 Dec 2012 10:39|
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