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31P Saturation Transfer and Phosphocreatine Imaging in the Monkey Brain

Mora, Bassem and Narasimhan, P. T. and Ross, Brian D. and Allman, John and Barker, Peter B. (1991) 31P Saturation Transfer and Phosphocreatine Imaging in the Monkey Brain. Proceedings of the National Academy of Sciences of the United States of America, 88 (19). pp. 8372-8376. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:MORpnas91

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Abstract

31 P magnetic resonance imaging with chemical-shift discrimination by selective excitation has been employed to determine the phosphocreatine (PCr) distribution in the brains of three juvenile macaque monkeys. PCr images were also obtained while saturating the resonance of the {gamma}-phosphate of ATP, which allowed the investigation of the chemical exchange between PCr and the {gamma}-phosphate of ATP catalyzed by creatine kinase. Superposition of the PCr images over the proton image of the same monkey brain revealed topological variations in the distribution of PCr and creatine kinase activity. PCr images were also obtained with and without visual stimulation. In two out of four experiments, an apparently localized decrease in PCr concentration was noted in visual cortex upon visual stimulation. This result is interpreted in terms of a possible role for the local ADP concentration in stimulating the accompanying metabolic response.


Item Type:Article
Additional Information:Copyright © 1991 by National Academy of Sciences Communicated by John D. Roberts, May 15, 1991 We thank Dr. V. Rajanayagam of Huntington Medical Research Institutes for help in processing the images. B.M. thanks Dr. Lloyd Smith of the University of California, San Francisco, for his encouragement. This work was supported by grants from the Magnetic Resonance Spectroscopy fund of the Huntington Medical Research Institutes, The L. K. Whittier Foundation of California, and The Norris Foundation, and by grants to J.A. from the Beckman Institute and Karl Kirchgessner Foundation. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Record Number:CaltechAUTHORS:MORpnas91
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:MORpnas91
Alternative URL:http://www.pnas.org/cgi/content/abstract/88/19/8372
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ID Code:1278
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:07 Jan 2006
Last Modified:14 Nov 2014 19:18

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