Jiang, Lily I. and Sternberg, Paul W. (1998) Interactions of EGF, Wnt and HOM-C genes specify the P12 neuroectoblast fate in C. elegans. Development, 125 (12). pp. 2337-2347. ISSN 0950-1991. http://resolver.caltech.edu/CaltechAUTHORS:JIAdev98
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We investigate how temporal and spatial interactions between multiple intercellular and intracellular factors specify the fate of a single cell in Caenorhabditis elegans. P12, which is a ventral cord neuroectoblast, divides postembryonically to generate neurons and a unique epidermal cell. Three classes of proteins are involved in the specification of P12 fate: the LIN-3/LET-23 epidermal growth factor signaling pathway, a Wnt protein LIN-44 and its candidate receptor LIN-17, and a homeotic gene product EGL-5. We show that LIN-3 is an inductive signal sufficient to promote the P12 fate, and the conserved EGF signaling pathway is utilized for P12 fate specification; egl-5 is a downstream target of the lin-3/let-23 pathway in specifying P12 fate; and LIN-44 and LIN-17 act synergistically with lin-3 in the specification of the P12 fate. The Wnt pathway may function early in development to regulate the competence of the cells to respond to the LIN-3 inductive signal.
|Additional Information:||Copyright © 1998 by Company of Biologists. Accepted 3 April; published on WWW 19 May 1998. We are grateful to Craig Hunter for sending us the egl-5 cDNA clone and the muIs13 strain. We thank Michael Herman for the lin-17(n671) lin-44(n1792) strain and for many stimulating discussions. We thank Michael Herman, Howard Lipshitz, Kai Zinn, Tom Clandinin, Maureen Barr, Jing Liu, Minqin Wang, Peter Becker, Marie-Anne Félix, Giovanni Lesa, Aidyl Gonzalez-Serrichio, Chris Lacenere, René Garcia and Bhagwati Gupta for comments on the manuscript. This work was supported by a USPHS grant HD23690 to P.W.S. and by the HHMI, with which P.W.S. is an investigator.|
|Subject Keywords:||EGF, HOM-C, Wnt, Cell fate specification, Gene interactions, Ceanorhabditis elegans|
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|Deposited On:||24 Dec 2008 00:45|
|Last Modified:||26 Dec 2012 10:40|
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