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Electrophysiological Organization of the Eye of Aplysia

Jacklet, Jon W. (1969) Electrophysiological Organization of the Eye of Aplysia. Journal of General Physiology, 53 (1). pp. 21-42. ISSN 0022-1295. http://resolver.caltech.edu/CaltechAUTHORS:JACjgp69

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Abstract

The eye of Aplysia californica was studied by electrophysiological and histological methods. It has a central spheroidal lens which is surrounded by a retina composed of several thousand receptor cells which are replete with clear vesicles, pigmented support cells, neurons which contain secretory granules, and glial cells. The thin optic nerve that connects the eye to the cerebral ganglion gives a simple "on" response of synchronized action potentials. Tonic activity occurs in the optic nerve in the dark and is dependent on previous dark adaptation. Micropipette recordings indicate that the ERG is positive (relative to a bathelectrode) on the outer surface of the eye and negative in the region of the distal segments of the receptors. Intracellular recordings show that receptor cells have resting potentials of 40–50 mv and respond to illumination with graded potentials of up to 55 mv. Dark-adapted receptors exhibit discrete bumps on the graded response to brief light flashes. Other elements in the retina that do not give large graded responses fall into two classes. One class responds to illumination with action potentials that are in synchrony with the extracellularly recorded compound optic nerve potentials. The other class is tonically active and is depolarized or hyperpolarized and inhibited upon illumination. It is apparent that complex excitatory and lateral inhibitory interactions occur among the elements of the retina.


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http://jgp.rupress.org/cgi/content/abstract/53/1/21PublisherUNSPECIFIED
Additional Information:Copyright © 1970 by The Rockefeller University Press. RUP grants the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode. Received for publication 31 May 1968. The author is grateful to Dr. Felix Strumwasser for constructive advice and support, Renate Alvarez for histological preparations, and James Gilliam for technical assistance. This work was supported by National Institutes of Health postdoctoral fellowship 1F2 NB 35,411 and National Institutes of Health grant NB07071 to Felix Strumwasser.
Funders:
Funding AgencyGrant Number
National Institutes of Health1F2 NB 35411
National Institutes of HealthNB07071
Record Number:CaltechAUTHORS:JACjgp69
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:JACjgp69
Usage Policy:RUP grants the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode.
ID Code:12793
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:24 Dec 2008 17:49
Last Modified:26 Dec 2012 10:40

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