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Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide

Goldstein, Avram and Fischli, Walter and Lowney, Louise I. and Hunkapiller, Michael and Hood, Leroy (1981) Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide. Proceedings of the National Academy of Sciences of the United States of America, 78 (11). pp. 7219-7223. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:GOLpnas81

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Abstract

The full primary structure of the very potent opioid peptide dynorphin, from porcine pituitary, has been determined. It is (H)Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln(OH). The synthetic peptide with this sequence behaves identically to natural dynorphin in a number of ways, and it has the same potency in the guinea pig ileum myenteric plexus-longitudinal muscle bioassay. The potency is accounted for by the first 13 residues.


Item Type:Article
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http://www.pnas.org/content/78/11/7219.abstractPublisherUNSPECIFIED
Additional Information:© 1981 by the National Academy of Sciences. Contributed by Avram Goldstein, August 24, 1981. We acknowledge the skilled technical assistance provided by Patricia Lowery, Asha Naidu, Keiko Otsu, and Vince Farnsworth. This investigation was supported by Grant DA-1199 from the National Institute on Drug Abuse (to A.G.), a grant from the Swiss National Foundation (to W.F.), a grant from the Weingart Foundation (to L.H.), and a generous gift from David Fasken to the Addiction Research Foundation. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Funders:
Funding AgencyGrant Number
National Institute on Drug AbuseDA-1199
Swiss National FoundationUNSPECIFIED
Weingart FoundationUNSPECIFIED
Addiction Research FoundationUNSPECIFIED
Subject Keywords:endorphin; [Leu]enkephalin; neuropeptide; opioid peptide
Record Number:CaltechAUTHORS:GOLpnas81
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:GOLpnas81
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13225
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Feb 2009 22:28
Last Modified:26 Dec 2012 10:46

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