De Schutter, Erik and Bower, James M. (1993) Sensitivity of synaptic plasticity to the Ca^(2+) permeability of NMDA channels : a model of long-term potentiation in hippocampal neurons. Neural Computation, 5 (5). pp. 681-694. ISSN 0899-7667. http://resolver.caltech.edu/CaltechAUTHORS:SCHUnc93
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We have examined a model by Holmes and Levy (1990) of the induction of associative long-term potentiation (LTP) by a rise in the free Ca^(2+) concentration ([Ca^(2+)]) after synaptic activation of dendritic spines. The previously reported amplification of the change in [Ca^(2+)] caused by coactivation of several synapses was found to be quite sensitive to changes in the permeability of the N-methyl-D-aspartate (NMDA) receptor channels to Ca^(2+). Varying this parameter indicated that maximum amplification is obtained at values that are close to Ca^(2+) permeabilities reported in the literature. However, amplification failed if permeability is reduced by more than 50%. We also found that the maximum free [Ca^(2+)] reached in an individual spine during synaptic coactivation of several spines depended on the location of that spine on the dendritic tree. Distal spines attained a higher [Ca^(2+)] than proximal ones, with differences of up to 80%. The implications of this result for the uniformity of induction of associative LTP in spines in different regions of the dendrite are discussed.
|Additional Information:||© 1993 Massachusetts Institute of Technology. Received 20 March 1992; accepted 25 January 1993; posted online April 4, 2008. This work was supported by Fogarty fellowship F05 TWO4368 to EDS and a grant from the Office of Naval Research, Contract N00014-91-5-1831. We thank the editors for useful comments on a first draft of this paper.|
|Subject Keywords:||MOUSE CENTRAL NEURONS; DENDRITIC SPINES; RECEPTOR CHANNELS; DIVALENT-CATIONS; PROTEIN-KINASE; CALCIUM; RESPONSES; INDUCTION; BLOCK; CA1|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Jason Perez|
|Deposited On:||25 Jun 2009 16:40|
|Last Modified:||26 Dec 2012 10:54|
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