Horn, D. and Ruppin, E. and Usher, M. and Herrmann, M. (1993) Neural network modeling of memory deterioration in Alzheimer's disease. Neural Computation, 5 (5). pp. 736-749. ISSN 0899-7667. http://resolver.caltech.edu/CaltechAUTHORS:HORnc93
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The clinical course of Alzheimer's disease (AD) is generally characterized by progressive gradual deterioration, although large clinical variability exists. Motivated by the recent quantitative reports of synaptic changes in AD, we use a neural network model to investigate how the interplay between synaptic deletion and compensation determines the pattern of memory deterioration, a clinical hallmark of AD. Within the model we show that the deterioration of memory retrieval due to synaptic deletion can be much delayed by multiplying all the remaining synaptic weights by a common factor, which keeps the average input to each neuron at the same level. This parallels the experimental observation that the total synaptic area per unit volume (TSA) is initially preserved when synaptic deletion occurs. By using different dependencies of the compensatory factor on the amount of synaptic deletion one can define various compensation strategies, which can account for the observed variation in the severity and progression rate of AD.
|Additional Information:||© 1993 Massachusetts Institute of Technology. Received 1 July 1992; accepted 14 January 1993. Posted Online April 4, 2008.|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||25 Mar 2009 20:44|
|Last Modified:||26 Dec 2012 10:55|
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