Acloque, Hervé and Adams, Meghan S. and FIshwick, Katherine and Nieto, M. Angela and Bronner, Marianne E. (2009) Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. Journal of Clinical Investigation, 119 (6). pp. 1438-1449. ISSN 0021-9738 http://resolver.caltech.edu/CaltechAUTHORS:20090709-100213332
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The events that convert adherent epithelial cells into individual migratory cells that can invade the extracellular matrix are known collectively as epithelial-mesenchymal transition (EMT). Throughout evolution, the capacity of cells to switch between these two cellular states has been fundamental in the generation of complex body patterns. Here, we review the EMT events that build the embryo and further discuss two prototypical processes governed by EMT in amniotes: gastrulation and neural crest formation. Cells undergo EMT to migrate and colonize distant territories. Not surprisingly, this is also the mechanism used by cancer cells to disperse throughout the body.
|Additional Information:||© 2009 American Society for Clinical Investigation. Published June 1, 2009. The work in our laboratories is supported by grants from the Spanish Ministry of Science and Innovation (grants BFU2005-05772, BFU2008-01042, NAN2004-09230-C04-04, CONSOLIDER-INGENIO 2010 CSD2007-00017 and CSD2007-00023) and the Generalitat Valenciana (Prometeo/2008/049) to M.A. Nieto; and by NIH grants R01 DE017911 and P50HG004071 to M. Bronner-Fraser. H. Acloque was supported by the I3P Programme (European Social Fund/MEC) and M.S. Adams by the Morgan fellowship from the Gordon and Betty Moore Foundation.|
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|Deposited By:||Jason Perez|
|Deposited On:||28 Jul 2009 20:49|
|Last Modified:||26 Dec 2012 11:04|
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