Aguzzi, Adriano and Steele, Andrew D. (2009) Prion topology and toxicity. Cell, 137 (6). pp. 994-996. ISSN 0092-8674 http://resolver.caltech.edu/CaltechAUTHORS:20090729-092723886
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Abstract
Inactivation of mahogunin, an E3 ubiquitin ligase, causes a spongiform encephalopathy resembling prion disease. Chakrabarti and Hegde (2009) now report that prion proteins with aberrant topologies inactivate mahogunin, providing a plausible explanation for certain aspects of prion pathology.
| Item Type: | Article | ||||||||||
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| Additional Information: | ©2009 Elsevier Inc. A.A. is supported by the Swiss National Foundation, European Union FP7, and the Stammbach Foundation. A.D.S. is supported by the Broad Fellows in Brain Circuitry program at Caltech. | ||||||||||
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| Record Number: | CaltechAUTHORS:20090729-092723886 | ||||||||||
| Persistent URL: | http://resolver.caltech.edu/CaltechAUTHORS:20090729-092723886 | ||||||||||
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| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||
| ID Code: | 14715 | ||||||||||
| Collection: | CaltechAUTHORS | ||||||||||
| Deposited By: | Ruth Sustaita | ||||||||||
| Deposited On: | 07 Aug 2009 20:59 | ||||||||||
| Last Modified: | 26 Dec 2012 11:06 |
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