Enami, Shinichi and Hoffmann, Michael R. and Colussi, A. J. (2009) Absorption of Inhaled NO_2. Journal of Physical Chemistry B, 113 (23). pp. 7977-7981. ISSN 1520-6106. http://resolver.caltech.edu/CaltechAUTHORS:20090821-081123560
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Nitrogen dioxide (NO_2), a sparingly water-soluble π-radical gas, is a criteria air pollutant that induces adverse health effects. How is inhaled NO_2(g) incorporated into the fluid microfilms lining respiratory airways remains an open issue because its exceedingly small uptake coefficient (γ 10^(−7)−10^(−8)) limits physical dissolution on neat water. Here, we investigate whether the biological antioxidants present in these fluids enhance NO_2(g) dissolution by monitoring the surface of aqueous ascorbate, urate, and glutathione microdroplets exposed to NO_2(g) for 1 ms via online thermospray ionization mass spectrometry. We found that antioxidants catalyze the hydrolytic disproportionation of NO_2(g), 2NO_2(g) + H_2O(l) = NO_3^−(aq) + H^+(aq) + HONO, but are not consumed in the process. Because this function will be largely performed by chloride, the major anion in airway lining fluids, we infer that inhaled NO_2(g) delivers H^+, HONO, and NO_3^− as primary transducers of toxic action without antioxidant participation.
|Additional Information:||Copyright © 2009 American Chemical Society. Received: March 24, 2009; Revised Manuscript Received: May 5, 2009. Publication Date (Web): May 15, 2009. S.E. thanks the Japan Society for the Promotion of Science Research Fellowship for Young Scientists. This project was supported by the National Science Foundation (ATM-0534990). Supporting Information: Additional data, data analysis, and experimental details. This material is available free of charge via the Internet at http://pubs.acs.org.|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||George Porter|
|Deposited On:||09 Sep 2009 17:57|
|Last Modified:||19 Jun 2015 18:39|
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