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Protein kinase C inhibitors prevent induction and continued expression of cell memory in Hermissenda type B photoreceptors

Farley, Joseph and Schuman, Erin (1991) Protein kinase C inhibitors prevent induction and continued expression of cell memory in Hermissenda type B photoreceptors. Proceedings of the National Academy of Sciences of the United States of America, 88 (5). pp. 2016-2020. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:FARpnas91

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Abstract

Injections of cAMP-dependent, Ca2+/calmodulin-dependent, or Ca2+/phospholipid-dependent protein kinases into Hermissenda crassicornis type B photoreceptors are sufficient to induce many of the changes in B-cell excitability produced by associative conditioning. We report that inhibitors of Ca2+/phospholipid-dependent protein kinases, but not inhibitors of cyclic nucleotide- or Ca2+/calmodulin-dependent protein kinases, prevent the induction as well as continued expression of learning-produced changes in type-B-cell excitability: reductions of voltage-dependent and Ca2+-activated K+ currents. Our results represent a direct demonstration of long-term (days) experientially induced modulation of ion-channel activity that is dependent upon persistent kinase activity.


Item Type:Article
Additional Information:Copyright © 1991 by the National Academy of Sciences. Communicated by James L. McGaugh, October 29, 1990. We thank Drs. Sidney Auerbach and Alexandra Newton for providing purified PKC. We thank Dr. Newton for useful discussions and critical reading of the manuscript. This work was supported in part by National Institutes of Health Grant NS26106. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Subject Keywords:ACTIVATION; SPECIFICITY; CURRENTS; BINDING; INACTIVATION; MECHANISM; INVITRO
Record Number:CaltechAUTHORS:FARpnas91
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:FARpnas91
Alternative URL:http://www.pnas.org/cgi/content/abstract/88/5/2016
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1591
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:01 Feb 2006
Last Modified:26 Dec 2012 08:45

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