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The WIGGUM gene is required for proper regulation of floral meristem size in Arabidopsis

Running, Mark P. and Fletcher, Jennifer C. and Meyerowitz, Elliot M. (1998) The WIGGUM gene is required for proper regulation of floral meristem size in Arabidopsis. Development, 125 (14). pp. 2545-2553. ISSN 0950-1991. http://resolver.caltech.edu/CaltechAUTHORS:20090925-105818247

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Abstract

The study of cell division control within developing tissues is central to understanding the processes of pattern formation. The floral meristem of angiosperms gives rise to floral organs in a particular number and pattern. Despite its critical role, little is known about how cell division is controlled in the floral meristem, and few genes involved have been identified. We describe the phenotypic effects of mutations in WIGGUM, a gene required for control of cell proliferation in the floral and apical meristem of Arabidopsis thaliana. wiggum flowers contain more organs, especially sepals and petals, than found in wild-type flowers. This organ number phenotype correlates with specific size changes in the early floral meristem, preceding organ initiation. Genetic studies suggest that WIGGUM acts on a similar process but in a separate pathway than the CLAVATA1 and CLAVATA3 genes in meristem size regulation, and reveal interactions with other genes affecting meristem structure and identity. Analysis of double mutant phenotypes also reveals a role for WIGGUM in apical meristem function. We propose that WIGGUM plays a role in restricting cell division relative to cellular differentiation in specific regions of the apical and floral meristems.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dev.biologists.org/cgi/content/abstract/125/14/2545PublisherUNSPECIFIED
Additional Information:Copyright © 1998 by Company of Biologists. Accepted 8 May; published on WWW 23 June 1998. We thank Detlef Weigel for providing the wig-1 mutant, and Adam Readhead and Jane Wei for assistance in the mapping of WIG. We thank Pat Koen for assistance with the scanning electron microscope, and Xuemei Chen, Jian Hua, Steven Jacobsen, Carolyn Ohno, Preeya Puangsomlee, Jose-Luis Reichmann, Robert Sablowski, Robert Williams, and Eva Ziegelhoffer for comments on the manuscript. This work was supported by NSF-MCB grant no. 9603821 to E. M. M. and NIH postdoctoral grant no. GM17868 to J. C. F. M. P. R was a Howard Hughes Predoctoral Fellow. This article is dedicated to the memory of Rebecca Rothenberg.
Funders:
Funding AgencyGrant Number
NSFMCB-9603821
NIHGM17868
Howard Hughes Medical InstituteUNSPECIFIED
Subject Keywords:Arabidopsis; WIGGUM (WIG); Floral meristem; Flower development; Pattern formation
Record Number:CaltechAUTHORS:20090925-105818247
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20090925-105818247
Official Citation: MP Running, JC Fletcher, and EM Meyerowitz The WIGGUM gene is required for proper regulation of floral meristem size in Arabidopsis Development 125: 2545-2553.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:16059
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:05 Oct 2009 16:20
Last Modified:26 Dec 2012 11:25

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