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Connections of thalamic modulatory centers to the vocal control system of the zebra finch

Akutagawa, Eugene and Konishi, Masakazu (2005) Connections of thalamic modulatory centers to the vocal control system of the zebra finch. Proceedings of the National Academy of Sciences of the United States of America, 102 (39). pp. 14086-14091. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:AKUpnas05

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Abstract

The vocal control system of zebra finches shows auditory gating in which neuronal responses to the individual bird's own song vary with behavioral states such as sleep and wakefulness. However, we know neither the source of gating signals nor the anatomical connections that could link the modulatory centers of the brain with the song system. Two of the song-control nuclei in the forebrain, the HVC (used as the proper name) and the interfacial nucleus of the nidopallium, both show auditory gating, and they receive input from the uvaeform nucleus (Uva) in the thalamus. We used a combination of anterograde and retrograde tracing methods to show that the dorsal part of the reticular formation and the medial habenula (MHb) project to the Uva. We also show by choline acetyl transferase immunohistochemistry that the MHb is cholinergic and sends cholinergic fibers to the Uva. Our findings suggest that the Uva might serve as a hub to coordinate neuromodulatory input into the song system.


Item Type:Article
Additional Information:Copyright © 2005 by the National Academy of Sciences. Contributed by Masakazu Konishi, August 5, 2005. Published online before print September 15, 2005, 10.1073/pnas.0506774102. We thank Gregory Ball, Richard Mooney, and Martin Wild for reviewing drafts of the manuscript. This work was supported by National Institutes of Health Grant MH55984.
Subject Keywords:AUDITORY GATING; CHOLINERGIC; SONG SYSTEM; THALAMUS; AVIAN SONG SYSTEM; CHOLINE-ACETYLTRANSFERASE; AUDITORY ACTIVITY; MEDIAL HABENULA; RETICULAR NUCLEUS; BEHAVIORAL STATE; MOTOR SYSTEM; MAST-CELLS; ACETYLCHOLINESTERASE; ORGANIZATION
Record Number:CaltechAUTHORS:AKUpnas05
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:AKUpnas05
Alternative URL:http://dx.doi.org/10.1073/pnas.0506774102
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1606
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:16 Mar 2006
Last Modified:14 Nov 2014 19:19

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