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Uniparental propagation of mitochondrial DNA in mouse-human cell hybrids

DeFrancesco, Laura and Attardi, Giuseppe and Croce, Carlo M. (1980) Uniparental propagation of mitochondrial DNA in mouse-human cell hybrids. Proceedings of the National Academy of Sciences of the United States of America, 77 (7). pp. 4079-4083. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:FRApnas80

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Abstract

The retention of the two parental mitochondrial DNAs has been investigated in a large number of mouse-human cell hybrids segregating either mouse or human chromosomes, by using a highly sensitive and specific method for detection of the DNA; the results have been correlated with the karyotype and isozyme marker pattern in the same hybrid lines. In all the hybrids examined, a consistent pattern was observed for the type of mitochondrial DNA retained: the mitochondrial DNA of the parent whose chromosomes were segregated from the nucleus was undetectable or present in marginal amounts. This was true also of hybrids containing a complete set of the segregating chromosomes in the total or a large fraction of the cell population.


Item Type:Article
Additional Information:Copyright © 1980 by the National Academy of Sciences. Communicated by Hilary Koprowski, March 13, 1980. This work was supported by Research Grant PCM-7718037 from the National Science Foundation and a Junior Fellowship of the American Cancer Society, California Division (to L.D.), and by grants from the National Institutes of Health and the National Foundation-March of Dimes. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U. S. C. §1734 solely to indicate this fact.
Subject Keywords:chromosomes; isozymes; restriction enzyme; Southern hybridization
Record Number:CaltechAUTHORS:FRApnas80
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:FRApnas80
Alternative URL:http://www.pnas.org/cgi/content/abstract/77/7/4079
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1614
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:07 Feb 2006
Last Modified:26 Dec 2012 08:45

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