Hule, Rohan A. and Nagarkar , Radhika P. and Hammouda, Boualem and Schneider , Joel P. and Pochan, Darrin J. (2009) Dependence of Self-Assembled Peptide Hydrogel Network Structure on Local Fibril Nanostructure. Macromolecules, 42 (18). pp. 7137-7145. ISSN 0024-9297 http://resolver.caltech.edu/CaltechAUTHORS:20091001-113544606
- Published Version
See Usage Policy.
- Supplemental Material
See Usage Policy.
Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20091001-113544606
Physically cross-linked, fibrillar hydrogel networks are formed by the self-assembly of β-hairpin peptide molecules with varying degrees of strand asymmetry. The peptide registry in the self-assembled state can be used as a design element to generate fibrils with twisting, nontwisting, or laminated morphology. The mass density of the networks varies significantly, and can be directly related to the local fibrillar morphology as evidenced by small angle neutron scattering (SANS) and in situ substantiation using cryogenic transmission electron microscopy (cryo-TEM) under identical concentrations and conditions. Similarly, the density of the network is dependent on changes in the peptide concentration. Bulk rheological properties of the hydrogels can be correlated to the fibrillar nanostructure, with the stiffer, laminated fibrils forming networks with a higher G′ as compared to the flexible, singular fibrillar networks.
|Additional Information:||© 2009 American Chemical Society. Received February 12, 2009; Revised Manuscript Received July 16, 2009. The identification of any commercial product or trade name does not imply endorsement or recommendation by the National Institute of Standards and Technology. This work was supported byNSFCHE0348323 (JPS-RPN), a Small Angle Neutron Scattering on Polymers and Complex Fluids Award (DJP-RAH, US Department of Commerce, # 70NANB7H6178), NIH 5RO1DEO16383, and the W. M. Keck Foundation for funding the College of Engineering Electron Microscopy Laboratory. This work utilized facilities supported in part by the National Science Foundation under Agreement No. DMR-0454672. Supporting Information Available: Cryo-TEM image analysis and AFM data with image analysis. This material is available free of charge via the Internet at http://pubs.acs.org.|
|Official Citation:||Dependence of Self-Assembled Peptide Hydrogel Network Structure on Local Fibril Nanostructure Rohan A. Hule, Radhika P. Nagarkar, Boualem Hammouda, Joel P. Schneider, Darrin J. Pochan Macromolecules 2009 42 (18), 7137-7145.|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||06 Oct 2009 20:07|
|Last Modified:||26 Dec 2012 11:26|
Repository Staff Only: item control page