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Life extension in Drosophila by feeding a drug

Kang, Hyung-Lyun and Benzer, Seymour and Min, Kyung-Tai (2002) Life extension in Drosophila by feeding a drug. Proceedings of the National Academy of Sciences of the United States of America, 99 (2). pp. 838-843. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:KANpnas02

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Abstract

We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state.


Item Type:Article
Additional Information:Copyright © 2002 by the National Academy of Sciences. Contributed by Seymour Benzer, November 28, 2001. Published online before print January 15, 2002, 0.1073/pnas.022631999. We especially thank Joseph Cooper at Medicis (Scottsdale, AZ) for his generous gift of PBA. This research, initiated at Caltech, was supported by an intramural grant to K.-T.M. from the National Institute of Neurological Disorders and Stroke and the Ellison Foundation, and grants to S.B. from the National Science Foundation, the National Institutes of Health, the Ellison Foundation, and the James G. Boswell Foundation.
Subject Keywords:HISTONE DEACETYLASE; GENE-EXPRESSION; CAENORHABDITIS-ELEGANS; SUPEROXIDE-DISMUTASE; OXIDATIVE STRESS; EXTENDED LIFE; SPAN; MELANOGASTER; OVEREXPRESSION; MUTANT
Record Number:CaltechAUTHORS:KANpnas02
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:KANpnas02
Alternative URL:http://dx.doi.org/10.1073/pnas.022631999
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1617
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:07 Feb 2006
Last Modified:14 Nov 2014 19:19

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