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Nitrogenase: A nucleotide-dependent molecular switch

Howard, James B. and Rees, Douglas C. (1994) Nitrogenase: A nucleotide-dependent molecular switch. Annual Review of Biochemistry, 63 . pp. 235-264. ISSN 0066-4154. http://resolver.caltech.edu/CaltechAUTHORS:HOWarb94

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Abstract

In the simplest terms, the biological nitrogen cycle is the reduction of atmospheric dinitrogen (N2) to ammonia with the subsequent reoxidation ammonia to dinitrogen (1). At the reduction level of ammonia, nitrogen incorporated into precursors for biological macromolecules such as proteins and nucleic acids. Reoxidation of ammonia to dinitrogen ("denitrification") by a variety of microbes (by way of nitrite and other oxidation levels of nitrogen) leads to the depletion of the "fixed," biologically usable, nitrogen pool. Besides the relatively small contribution from commercial ammonical fertilizer production, replenishing of the nitrogen pool falls mainly to a limited number of physiologically diverse microbes (e.g. eubacteria and archaebacteria; free-living and symbiotic; aerobic and anaerobic) that contain the nitrogenase enzyme system.


Item Type:Article
Additional Information:"Reprinted, with permission, from the Annual Review of Biochemistry, Volume 63 copyright 1994 by Annual Reviews, www.annualreviews.org" The efforts and contributions of J. Kim, M. Georgiadis, D. Woo, M. K. Chart, M. W. Day, J. Schlessman, H. Komiya, L. Joshua-Tot, M. H. B. Stowell, B. T. Hsu and A. J. Chirino are deeply appreciated, as are discussions, sharing of preprints, etc with our nitrogenase colleagues. Research in the authors’ laboratories was supported by grants from NIH and NSF.
Subject Keywords:NITROGEN FIXATION; NUCLEOTIDE-BINDING PROTEINS; ADP/ATP; ENZYME MECHANISM; METAL CLUSTERS; IRON-MOLYBDENUM COFACTOR; AZOTOBACTER-VINELANDII NITROGENASE; MAGNESIUM ADENOSINE 5'-TRIPHOSPHATE; ELECTRON-PARAMAGNETIC RESONANCE; SUBSTRATE REDUCTION PROPERTIES; KLEBSIELLA-PNEUMONIAE; FE-PROTEIN; CLOSTRIDIUM-PASTEURIANUM; HYDROGEN EVOLUTION; MOFE-PROTEIN
Record Number:CaltechAUTHORS:HOWarb94
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:HOWarb94
Alternative URL:http://dx.doi.org/10.1146/annurev.bi.63.070194.001315
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1624
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 Feb 2006
Last Modified:26 Dec 2012 08:45

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