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Nitric oxide and synaptic function

Schuman, Erin M. and Madison, Daniel V. (1994) Nitric oxide and synaptic function. Annual Review of Neuroscience, 17 . pp. 153-183. ISSN 0147-006X. http://resolver.caltech.edu/CaltechAUTHORS:SCHarn94

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Abstract

The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems. Whereas most neurotransmitters are packaged in synaptic vesicles and secreted in a Ca2+-dependent manner from specialized nerve endings, NO is an unconventional transmitter which is not packaged in vesicles, but rather diffuses from its site of production in the absence of any specialized release machinery. The lack of a requirement for release apparatus raises the possibility that NO can be released from both pre- and postsynaptic neuronal elements. In addition, because NO is gaseous and extremely membrane permeant, it can bypass normal signal transduction routes involving interactions with synaptic membrane receptors. Although the targets of NO have not yet been completely described, it is known that NO can bind to the iron contained in heine groups, leading to conformational changes in associated proteins, such as guanylyl cyclase.


Item Type:Article
Additional Information:"Reprinted, with permission, from the Annual Review of Neuroscience, Volume 17 copyright 1994 by Annual Reviews, www.annualreviews.org"
Subject Keywords:PLASTICITY; LONG-TERM POTENTIATION; LONG-TERM DEPRESSION; NMDA RECEPTOR; HIPPOCAMPUS; DEPENDENT PROTEIN-KINASE; ENDOGENOUS ADP-RIBOSYLATION; CEREBELLAR PURKINJE NEURONS; AORTIC ENDOTHELIAL-CELLS; REDOX MODULATORY SITE; MOUSE CENTRAL NEURONS; SMOOTH-MUSCLE CELLS; NADPH-DIAPHORASE; CYCLIC-GMP
Record Number:CaltechAUTHORS:SCHarn94
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:SCHarn94
Alternative URL:http://dx.doi.org/10.1146/annurev.ne.17.030194.001101
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1634
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Feb 2006
Last Modified:26 Dec 2012 08:45

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