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Biocompatible parylene neurocages developing a robust method for live neural network studies

Tooker, Angela and Meng, Ellis and Erickson, Jon and Tai, Yu-Chong and Pine, Jerry (2005) Biocompatible parylene neurocages developing a robust method for live neural network studies. IEEE Engineering in Medicine and Biology Magazine, 24 (6). pp. 30-33. ISSN 0739-5175. http://resolver.caltech.edu/CaltechAUTHORS:TOOieeeembm05

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Abstract

We present a refined method and design for fabricating parylene neurocages for in vitro studies of live neural networks. Parylene neurocages are biocompatible and very robust, making them ideally suited for studying the synaptic connections netween individual neurons to gain insight into learning and memory. The neurocage fabrication process is significantly less complex than earlier versions. Previous neurocage designs achieved limited neuronal outgrowth; however, the long-term cell survival rate was <25%. As outlined here, the incorporation of new materials and different anchoring techniques, in addition to some design modifications, have improved the long-term survival rate to >50%.


Item Type:Article
Additional Information:© 2005 IEEE. Reprinted with permission. This work was funded by the the National Institutes of Health (R01 NSO44134). We would like to thank Trevor Roper, Qing He, and Angelique Johnson for assistance with fabrication and testing.
Record Number:CaltechAUTHORS:TOOieeeembm05
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:TOOieeeembm05
Alternative URL:http://dx.doi.org/10.1109/MEMB.2005.1549727
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1650
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:09 Feb 2006
Last Modified:26 Dec 2012 08:45

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